ArticleThe journal of pain2012
Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.
Article in The journal of pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 90 citations in OpenAlex.
- Clinical Efficacy of Erector Spinae Plane Block for Pain Management After Breast Surgeries: A Narrative Review.Current pain and headache reports · 2025Review
- Research progress of breast cancer surgery during 2010-2024: a bibliometric analysis.Frontiers in oncology · 2024Article
- A Pilot Study of Associations Between the Occurrence of Palpitations and Cytokine Gene Variations in Women Prior to Breast Cancer Surgery.Biological research for nursing · 2023Article
- Pain associated with breast cancer: etiologies and therapies.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Article
- Characteristics associated with inter-individual variability in financial distress in patients with breast cancer prior to and for 12 months following surgery.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Distinct employment interference profiles in patients with breast cancer prior to and for 12 months following surgery.BMC cancer · 2021Article
- Chronic Breast Pain Prior to Breast Cancer Surgery Is Associated with Worse Acute Postoperative Pain Outcomes.Journal of clinical medicine · 2021Article
- Epidemiology and Predictive Factors for Persistent Breast Pain Following Breast-Conserving Surgery.Cureus · 2021Article
- BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells.American journal of respiratory cell and molecular biology · 2021Article
- Changes in Attentional Function in Patients From Before Through 12 Months After Breast Cancer Surgery.Journal of pain and symptom management · 2020Article
- Post-mastectomy and post-breast conservation surgery pain syndrome: a review of etiologies, risk prediction, and trends in management.Translational cancer research · 2020Article
- Associations Between Catecholaminergic and Serotonergic Genes and Persistent Arm Pain Severity Following Breast Cancer Surgery.The journal of pain · 2019Article
- Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain.International journal of molecular sciences · 2019Review
- Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study.Human genomics · 2019Article
- Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management.Seminars in oncology nursing · 2019Review
- A Pilot Study Using a Multistaged Integrated Analysis of Gene Expression and Methylation to Evaluate Mechanisms for Evening Fatigue in Women Who Received Chemotherapy for Breast Cancer.Biological research for nursing · 2019Article
- Neuraxial Cytokines in Pain States.Frontiers in immunology · 2019Review
- Menopausal-Related Symptoms in Women One Year After Breast Cancer Surgery.Journal of pain and symptom management · 2018Article
- Differences in symptom clusters before and twelve months after breast cancer surgery.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2018Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledThe purposes of this study were to determine the occurrence rate for preoperative breast pain; describe the characteristics of this pain; evaluate for differences in demographic and clinical characteristics; and evaluate for variations in pro- and anti-inflammatory cytokine genes between women who did and did not report pain. Patients (n = 398) were recruited prior to surgery and completed self-report questionnaires on a number of pain characteristics. Genotyping was done using a custom genotyping array. Women (28.2%) who reported breast pain were significantly younger (P < .001); more likely to be nonwhite (P = .032); reported significantly lower Karnofsky Performance Status scores (P = .008); were less likely to be postmenopausal (P = .012); and had undergone significantly more biopsies (P = .006). Carriers of the minor allele for a single nucleotide polymorphism in interleukin (IL)1-receptor 1 (IL1R1) (rs2110726) were less likely to report breast pain prior to surgery (P = .007). Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast pain prior to surgery (P = .019). Findings suggest that breast pain occurs in over a quarter of women who are about to undergo breast cancer surgery. Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative breast pain. PERSPECTIVE: In women with breast cancer, preoperative pain may be associated with increases in inflammatory responses associated with an increased number of biopsies. In addition, differences in cytokine genes may contribute to this preoperative breast pain.
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