Evidence map›Paper›PMID 22515912›Full record

ArticleEmerging infectious diseases2012

Invasive Haemophilus influenzae serotype e and f disease, England and Wales.

Shamez N Ladhani, Sarah Collins, Anna Vickers, David J Litt, Carina Crawford, Mary E Ramsay, Mary P E Slack

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Rare serotype c Haemophilus influenzae invasive isolate: characterization of the first case in Portugal.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  3. Frontiers in microbiology · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Effect of Haemophilus influenzae Type b and 13-Valent Pneumococcal Conjugate Vaccines on Childhood Pneumonia Hospitalizations and Deaths in Botswana.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  9. Review
  10. Review
  11. Article
  12. Epidemiology of Haemophilus influenzae in the Republic of Ireland, 2010-2018.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  13. Molecular epidemiology of invasive Haemophilus influenzae disease in Portugal: an update of the post-vaccine period, 2011-2018.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  14. Article
  15. Article
  16. Two cases of type-aMicrobial genomics · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shamez N LadhaniHealth Protection Agency, London, UK. shamez.ladhani@hpa.org.uk
Sarah Collins
Anna Vickers
David J Litt
Carina Crawford
Mary E Ramsay
Mary P E Slack

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Haemophilus influenzae infection causes serious invasive disease, but incidence of the most virulent serotype, Hib, has dropped since introduction of routine Hib vaccination. In England and Wales, the incidence of 2 other serotypes, Hie and Hif, is increasing; during 2001-2010, there was an 11.0% year-on-year increase in Hif and a 7.4% increase in Hie. In 2009-2010, Hif incidence was 0.090/100,000 persons and Hie incidence 0.030/100,000, with higher rates among infants and older adults. Hie had a more severe clinical course; although outcome at 6 months was comparable for the 2 serotypes, case-fatality rate within 7 days of diagnosis was higher for Hie, even after adjustment for age and comorbidities. Multilocus sequence typing revealed a single major circulating clone for both Hif (sequence type 124; 89/99 isolates, 90%) and Hie (sequence type 18; 21/33, 64%), but no association between type and clinical disease or outcome was found.

Indexed as

AdolescentAdultAgedAge FactorsChildChild, PreschoolEnglandHaemophilus InfectionsHaemophilus influenzaeHumansIncidenceInfantInfant, NewbornMiddle AgedMultilocus Sequence TypingSerotyping

Identifiers

PMID22515912
PMCPMC3358072
OpenAlexW2002190345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.