ArticleJournal of endodontics2012
Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response.
Article in Journal of endodontics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 96 citations in OpenAlex.
- WNT gene polymorphisms and predisposition to apical periodontitis.Scientific reports · 2019Trial
- A Study ofBioMed research international · 2017Trial
- Examining Electronic Health Records to Investigate Sex Differences in Oral Diseases and Conditions.Clinical and experimental dental research · 2026Article
- The Effect of Genetics on Caries Risk Assessment: MMP3 (rs679620) and VDR (rs731236) Gene Polymorphisms.Oral health & preventive dentistry · 2026Article
- Genetic variants associated with systemic inflammatory disease associate with temporomandibular symptoms with or without periodontitis.PloS one · 2026Article
- Genome-wide association study of pulpal and apical diseases.Nature communications · 2025Article
- Genetic Analysis ofGenes · 2025Article
- Review
- Matrix metalloproteinase 9 level changes in gingival crevicular fluid samples of teeth with acute and chronic apical periodontitis.Dental research journal · 2024Article
- Genome-wide Association Study Identifies Novel Risk Loci for Apical Periodontitis.Journal of endodontics · 2023Article
- Genome-wide association study identifies novel risk loci for apical periodontitis.Research square · 2023Article
- Association of MMP2 and MMP9 gene polymorphisms with nonsyndromic cleft lip/palate in an Iranian population.Journal of dental research, dental clinics, dental prospects · 2023Article
- Risk factor of elevated matrix metalloproteinase-3 gene expression in synovial fluid in knee osteoarthritis women.PloS one · 2023Article
- Reactive Oxygen Species Enlightened Therapeutic Strategy for Oral and Maxillofacial Diseases-Art of Destruction and Reconstruction.Biomedicines · 2022Review
- Clinical influence of calcium hydroxide intracanal medications on matrix metalloproteinases and tissue inhibitors of metalloproteinases in apical periodontitis.Clinical oral investigations · 2022Article
- The Wnt/β-catenin signaling pathway has a healing ability for periapical periodontitis.Scientific reports · 2021Article
- Matrix metalloproteinases gene variants and dental caries in Czech children.BMC oral health · 2020Article
- Genetic and Epigenetic Characterization of Pulpal and Periapical Inflammation.Frontiers in physiology · 2020Review
- Article
- Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms.Frontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionIt has been proposed that individual genetic predisposition may contribute to a persistent apical periodontitis condition. Matrix metalloproteinases (MMPs) are associated with levels of inflammation and are involved in caries, pulpal, and periapical tissue destruction. MMPs also play a major role in bone resorption. In this study, we hypothesized that polymorphisms in MMP genes and their regulators may contribute to an individual's increased susceptibility to apical tissue destruction in response to deep carious lesions.
methodsSixteen hundred radiographic records obtained through the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository were screened for subjects with deep carious lesions in dentin with or without periapical lesions (≥ 3 mm). DNA samples of 268 patients were sorted into 2 groups: 158 cases with deep carious lesions but no periapical lesions (controls) and 110 cases with periapical lesions and deep carious lesions (cases). Sixteen SNP markers in MMP2, MMP3, MMP9, MMP13, MMP14, and TIMP2, were selected for genotyping. Genotypes were generated by endpoint analysis in a real-time polymerase chain reaction instrument. Analyses were performed comparing cases and controls. Allele and genotypic frequencies and haplotype analysis were calculated using the PLINK program.
resultsAn association was found for MMP3 rs639752 (P = .03) and rs679620 (P = .004) genotypes in individuals with periapical lesions. We also observed altered transmission of MMP2 marker haplotypes (P = .000004) in these individuals.
conclusionsVariations in MMP2 and MMP3 are associated with periapical lesion formation in individuals with untreated deep carious lesions. Future studies could help predict host susceptibility to developing periapical lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.