Evidence map›Paper›PMID 22515699›Full record

ReviewNeurocase2013

Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship.

Brianne Magouirk Bettcher, Joel H Kramer

Abstract readReview
In one paragraph

Review in Neurocase, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Blueberries Improve Neuroinflammation and Cognition differentially Depending on Individual Cognitive baseline Status.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Neuroprotective effect of paeoniflorin on HExperimental and therapeutic medicine · 2015
    Article
  17. Article
  18. Review
  19. Article
  20. Frontotemporal dementia: diagnosis, deficits and management.Neurodegenerative disease management · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brianne Magouirk BettcherNeurology Department, Memory and Aging Center, University of California, San Francisco, CA 94143-1207, USA. bbettcher@memory.ucsf.edu
Joel H Kramer

Funding

PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Cognitive and Neural Correlates of Inflammation in Healthy Older AdultsK23AG042492 · NIA · UNIVERSITY OF COLORADO DENVER · PI BETTCHER, BRIANNE MAGOUIRK · 2012 to 2016
$716k
NIA NIH HHS K23 AG042492NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289
6 · The paper itself

Abstract

A proposed immune mechanism that potentially modifies or exacerbates neurodegenerative disease presentation in older adults has received considerable attention in the past decade, with recent studies demonstrating a strong link between pro-inflammatory markers and neurodegeneration. The overarching aim of the following review is to synthesize recent research that supports a possible relationship between inflammation and clinical features of neurodegenerative diseases, including risk of development, cognitive and clinical correlates, and progression of the specified diseases. Specific emphasis is placed on providing a temporal context for the association between inflammation and neurodegeneration.

Indexed as

Cognition DisordersEncephalitisHumansNeurodegenerative DiseasesTime Factors

Identifiers

PMID22515699
PMCPMC3733377

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.