ArticleLangmuir : the ACS journal of surfaces and colloids2012
In situ measurement of bovine serum albumin interaction with gold nanospheres.
Article in Langmuir : the ACS journal of surfaces and colloids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Deciphering the formation of biogenic nanoparticles and their protein corona: State-of-the-art and analytical challenges.Analytical and bioanalytical chemistry · 2026Review
- Investigation of Akt1 behavior on gold surface from molecular dynamics insight.Scientific reports · 2025Article
- Simultaneous Sizing and Refractive Index Analysis of Heterogeneous Nanoparticle Suspensions.ACS nano · 2023Article
- Small organic molecules containing amorphous calcium phosphate: synthesis, characterization and transformation.Frontiers in bioengineering and biotechnology · 2023Article
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- Mesoporous Silica Nanoparticles Functionalized with Amino Groups for Biomedical Applications.ChemistryOpen · 2021Article
- Synthesis of a High Affinity Complementary Peptide-Polymer Nanoparticle (NP) Pair Using Phage Display.ACS applied bio materials · 2021Article
- Thermodynamic Implications and Time Evolution of the Interactions of Near-Infrared PbS Quantum Dots with Human Serum Albumin.ACS omega · 2021Article
- Effects of Surface Protein Adsorption on the Distribution and Retention of Intratumorally Administered Gold Nanoparticles.Pharmaceutics · 2021Article
- Comparative Analysis of Au and Au@SiOACS omega · 2020Article
- Present and Future of Surface-Enhanced Raman Scattering.ACS nano · 2020Article
- Reactions of Medicinal Gold(III) Compounds With Proteins and Peptides Explored by Electrospray Ionization Mass Spectrometry and Complementary Biophysical Methods.Frontiers in chemistry · 2020Article
- Formation and Stabilization of Gold Nanoparticles in Bovine Serum Albumin Solution.Molecules (Basel, Switzerland) · 2019Article
- SERS Probing of Proteins in Gold Nanoparticle Agglomerates.Frontiers in chemistry · 2019Article
- Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications.Chemical Society reviews · 2018Review
- Modular assembly of proteins on nanoparticles.Nature communications · 2018Article
- Article
- Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing.Journal of extracellular vesicles · 2018Article
- Intrinsic peroxidase-like activity of rhodium nanoparticles, and their application to the colorimetric determination of hydrogen peroxide and glucose.Mikrochimica acta · 2017Article
- Sensitive Analysis of Protein Adsorption to Colloidal Gold by Differential Centrifugal Sedimentation.Analytical chemistry · 2017Article
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5 authors.
Funding
Abstract
We present in situ observations of adsorption of bovine serum albumin (BSA) on citrate-stabilized gold nanospheres. We implemented scattering correlation spectroscopy as a tool to quantify changes in the nanoparticle brownian motion resulting from BSA adsorption onto the nanoparticle surface. Protein binding was observed as an increase in the nanoparticle hydrodynamic radius. Our results indicate the formation of a protein monolayer at similar albumin concentrations as those found in human blood. Additionally, by monitoring the frequency and intensity of individual scattering events caused by single gold nanoparticles passing the observation volume, we found that BSA did not induce colloidal aggregation, a relevant result from the toxicological viewpoint. Moreover, to elucidate the thermodynamics of the gold nanoparticle-BSA association, we measured an adsorption isotherm which was best described by an anticooperative binding model. The number of binding sites based on this model was consistent with a BSA monolayer in its native state. In contrast, experiments using poly(ethylene glycol)-capped gold nanoparticles revealed no evidence for adsorption of BSA.
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