ArticleOrganic letters2012
Ammosamide D, an oxidatively ring opened ammosamide analog from a marine-derived Streptomyces variabilis.
Article in Organic letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Actinomycetota-Derived Metabolites in Pancreatic Cancer: Chemical Diversity, Metabolic Vulnerability, and Translational Barriers.Current oncology reports · 2026Review
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review.Frontiers in pharmacology · 2022Review
- Cytotoxic compounds from marine actinomycetes: Sources, Structures and Bioactivity.Acta materia medica · 2022Article
- Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis.Journal of industrial microbiology & biotechnology · 2021Article
- A Review: Halogenated Compounds from Marine Actinomycetes.Molecules (Basel, Switzerland) · 2021Review
- Deep Hypersaline Anoxic Basins as Untapped Reservoir of Polyextremophilic Prokaryotes of Biotechnological Interest.Marine drugs · 2020Review
- Bioactivities of Halometabolites from Marine Actinobacteria.Biomolecules · 2019Review
- Biologically active quinoline and quinazoline alkaloids part II.Medicinal research reviews · 2018Review
- Quinoline and naphthalene derivatives from Saccharopolyspora sp. YIM M13568.The Journal of antibiotics · 2017Article
- Article
- Review
- Discoipyrroles A-D: isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis.Journal of the American Chemical Society · 2013Article
- Systematic and biotechnological aspects of halophilic and halotolerant actinomycetes.Extremophiles : life under extreme conditions · 2013Article
- Precursor-Directed Generation of Amidine Containing Ammosamide Analogs: Ammosamides E-P.Chemical science · 2013Article
- Anthraquinones from a marine-derived Streptomyces spinoverrucosus.Journal of natural products · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Ammosamide D (1), an oxidized analog of the ammosamide family, was isolated from a marine-derived Streptomyces variabilis. Pyrroloquinoline containing alkaloids are a growing class of natural products, with 1 being the first example of an oxidized analog resulting in a 5,6-dioxo-5,6-dihydroquinoline ring system. Attempts at chemical conversion of ammosamide B to ammosamide D revealed that a strong chemical oxidant is required. Ammosamide D has modest cytotoxicity to the MIA PaCa-2 pancreatic cancer cell line.
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Registered trials
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