ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2012
Isolation of filamentous fungi from sputum in asthma is associated with reduced post-bronchodilator FEV1.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Microbiota Emergencies in the Diagnosis of Lung Diseases: A Meta-Analysis.Frontiers in cellular and infection microbiology · 2021Pooled it
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- Observational
- Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop.International forum of allergy & rhinology · 2025Review
- Positive sputum fungal culture, fungal sensitisation, and airway microbial diversity in asthmatic children.Medical mycology · 2025Article
- Effects of staphylococcal enterotoxin and fungal sensitization on clinical outcomes of asthma.European journal of medical research · 2024Article
- Fungal lung disease.The European respiratory journal · 2024Review
- Frequency and Distribution of Broncho-Alveolar Fungi in Lung Diseases in Martinique.Journal of clinical medicine · 2023Article
- Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide.Respiratory research · 2021Article
- Allergic fungal airways disease (AFAD): an under-recognised asthma endotype.Mycopathologia · 2021Review
- New Perspectives in the Diagnosis and Management of Allergic Fungal Airway Disease.Journal of asthma and allergy · 2021Review
- The role of antifungals in the management of patients with severe asthma.Clinical and translational allergy · 2020Review
- Review
- Effectiveness of Low-Dose Itraconazole in Fungal-Associated Severe Asthma: A Retrospective Study.Journal of asthma and allergy · 2020Article
- Fungal and bacterial microbiome dysbiosis and imbalance of trans-kingdom network in asthma.Clinical and translational allergy · 2020Article
- Comparative Analysis of Clinical Parameters and Sputum Biomarkers in Establishing the Relevance of Filamentous Fungi in Cystic Fibrosis.Frontiers in cellular and infection microbiology · 2020Article
- Smoking and microbiome in oral, airway, gut and some systemic diseases.Journal of translational medicine · 2019Review
- High burden of Aspergillus fumigatus infection among chronic respiratory diseases.Chronic respiratory disease · 2018Article
- Article
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFungal sensitization is common in severe asthma, but the clinical relevance of this and the relationship with airway colonization by fungi remain unclear. The range of fungi that may colonize the airways in asthma is unknown.
objectiveTo provide a comprehensive analysis on the range of filamentous fungi isolated in sputum from people with asthma and report the relationship with their clinico-immunological features of their disease.
methodsWe recruited 126 subjects with a diagnosis of asthma, 94% with moderate-severe disease, and 18 healthy volunteers. At a single stable visit, subjects underwent spirometry; sputum fungal culture and a sputum cell differential count; skin prick testing to both common aeroallergens and an extended fungal panel; specific IgE to Aspergillus fumigatus. Fungi were identified by morphology and species identity was confirmed by sequencing. Four patients had allergic bronchopulmonary aspergillosis.
resultsForty-eight percent of asthma subjects were IgE-sensitized to one fungal allergen and 22% to ≥ 2. Twenty-seven different taxa of filamentous fungi were isolated from 54% of their sputa, more than one species being detected in 17%. This compared with 3 (17%) healthy controls culturing any fungus (P < 0.01). Aspergillus species were most frequently cultured in isolation followed by Penicillium species. Post-bronchodilator FEV (1) (% predicted) in the subjects with asthma was 71(± 25) in those with a positive fungal culture vs. 83 (± 25) in those culture-negative, (P < 0.01). CONCLUSION AND CLINICAL RELEVANCE: Numerous thermotolerant fungi other than A. fumigatus can be cultured from sputum of people with moderate-to-severe asthma; a positive culture is associated with an impaired post-bronchodilator FEV (1) , which might be partly responsible for the development of fixed airflow obstruction in asthma. Sensitization to these fungi is also common.
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Registered trials
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