Evidence map›Paper›PMID 22515190›Full record

ArticleHealth services research2012

Looking to the future: incorporating genomic information into disparities research to reduce measurement error and selection bias.

Alexandra E Shields, William H Crown

Open access · greenAbstract read
In one paragraph

Article in Health services research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Equity in Genomic Medicine.Annual review of genomics and human genetics · 2022
    Review
  2. Article
  3. Article
  4. Article
  5. Taking the measure of health care disparities.Health services research · 2012
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexandra E ShieldsHarvard/MGH Center for Genomics, Vulnerable Populations and Health Disparities, and Mongan Institute for Health Policy, Massachusetts General Hospital, Boston, MA, USA. ashields@partners.org
William H Crown
HealthInsight · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Lay Understanding of Race, Addiction and GeneticsR01HG003475 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI SHIELDS, ALEXANDRA E · 2006 to 2011
$2.0M
NCRR NIH HHS UL1 RR 025758NCRR NIH HHS UL1 RR025758NHGRI NIH HHS R01 HG003475
6 · The paper itself

Abstract

objectiveTo extend recent conceptual and methodological advances in disparities research to include the incorporation of genomic information in analyses of racial/ethnic disparities in health care and health outcomes. DATA SOURCES: Published literature on human genetic variation, the role of genetics in disease and response to treatment, and methodological developments in disparities research. STUDY

designWe present a conceptual framework for incorporating genomic information into the Institute of Medicine definition of racial/ethnic disparities in health care, identify key concepts used in disparities research that can be informed by genomics research, and illustrate the incorporation of genomic information into current methods using the example of HER-2 mutations guiding care for breast cancer. PRINCIPAL

findingsGenomic information has not yet been incorporated into disparities research, though it has direct relevance to concepts of race/ethnicity, health status, appropriate care, and socioeconomic status. The HER-2 example demonstrates how available genetic information can be incorporated into current disparities methods to reduce selection bias and measurement error. Advances in health information infrastructure may soon make standardized genetic information more available to health services researchers.

conclusionGenomic information can refine measurement of racial/ethnic disparities in health care and health outcomes and should be included wherever possible in disparities research.

Indexed as

GenomicsHealth Status DisparitiesBreast NeoplasmsFemaleGenes, erbB-2Healthcare DisparitiesHealth StatusHumansRacial GroupsSelection BiasSocioeconomic FactorsSociology, Medical

Identifiers

PMID22515190
PMCPMC3418832
OpenAlexW2056748694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.