ArticlePloS one2012
Structural basis of the chromodomain of Cbx3 bound to methylated peptides from histone h1 and G9a.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Integrated Lactylome Characterization Reveals the Molecular Dynamics of Protein Regulation in Gastrointestinal Cancers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review
- CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression.International journal of biological sciences · 2022Article
- The missing linkGenes & development · 2021Review
- Article
- CBX3/HP1γ promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma.Aging · 2019Article
- Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis.The Journal of biological chemistry · 2019Article
- The interplay between H2A.Z and H3K9 methylation in regulating HP1α binding to linker histone-containing chromatin.Nucleic acids research · 2018Article
- Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.Development (Cambridge, England) · 2017Article
- Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8.Acta crystallographica. Section D, Biological crystallography · 2015Article
- Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.Molecular & cellular proteomics : MCP · 2015Article
- The functional diversity of protein lysine methylation.Molecular systems biology · 2014Review
- HP1a: a structural chromosomal protein regulating transcription.Trends in genetics : TIG · 2014Review
- A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.Nature · 2013Article
- Structural plasticity in human heterochromatin protein 1β.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHP1 proteins are highly conserved heterochromatin proteins, which have been identified to be structural adapters assembling a variety of macromolecular complexes involved in regulation of gene expression, chromatin remodeling and heterochromatin formation. Much evidence shows that HP1 proteins interact with numerous proteins including methylated histones, histone methyltransferases and so on. Cbx3 is one of the paralogues of HP1 proteins, which has been reported to specifically recognize trimethylated histone H3K9 mark, and a consensus binding motif has been defined for the Cbx3 chromodomain. METHODOLOGY/PRINCIPAL
findingsHere, we found that the Cbx3 chromodomain can bind to H1K26me2 and G9aK185me3 with comparable binding affinities compared to H3K9me3. We also determined the crystal structures of the human Cbx3 chromodomain in complex with dimethylated histone H1K26 and trimethylated G9aK185 peptides, respectively. The complex structures unveil that the Cbx3 chromodomain specifically bind methylated histone H1K26 and G9aK185 through a conserved mechanism. CONCLUSIONS/SIGNIFICANCE: The Cbx3 chromodomain binds with comparable affinities to all of the methylated H3K9, H1K26 and G9aK185 peptides. It is suggested that Cbx3 may regulate gene expression via recognizing both histones and non-histone proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.