Trial reportPloS one2012
Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence, predictors and adverse perinatal outcomes of placental malaria in sub-Saharan Africa: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2025Pooled it
- A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso.Malaria journal · 2020Trial
- Malaria and gravidity interact to modify maternal haemoglobin concentrations during pregnancy.Malaria journal · 2012Trial
- Uptake and Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine during Pregnancy in Africa: A Scoping Review.Diseases (Basel, Switzerland) · 2024Article
- Retrospective study of toxoplasmosis prevalence in pregnant women in Benin and its relation with malaria.PloS one · 2022Article
- Suboptimal Intermittent Preventive Treatment in Pregnancy (IPTp) is Associated With an Increased Risk of Submicroscopic Plasmodium falciparum Infection in Pregnant Women: A Prospective Cohort Study in Benin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Effectiveness of intermittent preventive treatment with Sulfadoxine-Pyrimethamine in pregnant women in San Pedro, Côte D'Ivoire.Pathogens and global health · 2021Article
- Submicroscopic placental infection by non-falciparum Plasmodium spp.PLoS neglected tropical diseases · 2018Article
- Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria.Scientific reports · 2017Article
- Predictors of the use of interventions to prevent malaria in pregnancy in Cameroon.Malaria journal · 2017Article
- Malaria in Pregnancy Is a Predictor of Infant Haemoglobin Concentrations during the First Year of Life in Benin, West Africa.PloS one · 2015Article
- High rates of parasite recrudescence following intermittent preventive treatment with sulphadoxine-pyrimethamine during pregnancy in Benin.Malaria journal · 2013Article
- Malaria and fetal growth alterations in the 3(rd) trimester of pregnancy: a longitudinal ultrasound study.PloS one · 2013Article
- Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.PloS one · 2013Article
- [Intermittent preventive treatment with sulfadoxine--pyrimethamine for malaria in pregnant women: efficacy and compliance in two urban hospitals in Burkina Faso].The Pan African medical journal · 2013Article
- The relationship between malaria parasitemia, malaria preventive measures and average birth weight of babies in a tertiary facility in Owerri, Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the consequences of intermittent preventive treatment (IPTp) timing on birth weight, we pooled data from two studies conducted in Benin between 2005 and 2010: a prospective cohort of 1037 pregnant women and a randomised trial comparing sulfadoxine-pyrimethamine (SP) to mefloquine in 1601 women. A total of 1439 women (752 in the cohort and 687 in the SP arm of the randomised trial) who delivered live singletons were analysed. We showed that an early intake of the first SP dose (4 months of gestation) was associated with a lower risk of LBW compared to a late intake (6-7 months of gestation) (aOR = 0.5 p = 0.01). We also found a borderline increased risk of placental infection when the first SP dose was administered early in pregnancy (aOR = 1.7 p = 0.1). This study is the first to investigate the timing of SP administration during pregnancy. We clearly demonstrated that women who had an early intake of the first SP dose were less at risk of LBW compared to those who had a late intake. Pregnant women should be encouraged to attend antenatal visits early to get their first SP dose and a third dose of SP could be recommended to cover the whole duration of pregnancy and to avoid late infections of the placenta.
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