ArticlePloS one2012
α7-Nicotinic acetylcholine receptor: role in early odor learning preference in mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Non-Motor Symptoms in Myasthenia Gravis Patients: Evaluation of Auditory and Olfactory Functions.Noro psikiyatri arsivi · 2026Article
- Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Aversive learning-induced plasticity throughout the adult mammalian olfactory system: insights across development.Journal of bioenergetics and biomembranes · 2019Review
- Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning.Frontiers in behavioral neuroscience · 2019Article
- Differential Muscarinic Modulation in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: implications for schizophrenia.Molecular and cellular neurosciences · 2014Article
- Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.Neurobiology of disease · 2014Article
- Paying attention to smell: cholinergic signaling in the olfactory bulb.Frontiers in synaptic neuroscience · 2014Review
- α7-Containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability.Journal of neurophysiology · 2013Article
- Nicotinic receptors modulate olfactory bulb external tufted cells via an excitation-dependent inhibitory mechanism.Journal of neurophysiology · 2013Article
- The dominant functional nicotinic receptor in progenitor cells in the rostral migratory stream is the α3β4 subtype.Journal of neurophysiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Recently, we have shown that mice with decreased expression of α7-nicotinic acetylcholine receptors (α7) in the olfactory bulb were associated with a deficit in odor discrimination compared to wild-type mice. However, it is unknown if mice with decreased α7-receptor expression also show a deficit in early odor learning preference (ELP), an enhanced behavioral response to odors with attractive value observed in rats. In this study, we modified ELP methods performed in rats and implemented similar conditions in mice. From post-natal days 5-18, wild-type mice were stroked simultaneously with an odor presentation (conditioned odor) for 90 s daily. Control mice were only stroked, exposed to odor, or neither. On the day of testing (P21), mice that were stroked in concert with a conditioned odor significantly investigated the conditioned odor compared to a novel odor, as observed similarly in rats. However, mice with a decrease in α7-receptor expression that were stroked during a conditioned odor did not show a behavioral response to that odorant. These results suggest that decreased α7-receptor expression has a role in associative learning, olfactory preference, and/or sensory processing deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.