ArticlePloS one2012
Heterogeneous glycation of cancellous bone and its association with bone quality and fragility.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Methods for bone quality assessment in human bone tissue: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Circulating osteogenic progenitors and osteoclast precursors are associated with long-term glycemic control, sex steroids, and visceral adipose tissue in men with type 2 diabetes mellitus.Frontiers in endocrinology · 2022Trial
- Article
- Microdamage in biological hard tissues and its repair mechanisms.Biomedical engineering online · 2025Review
- Article
- Exploring the Intersection of Diabetes and Musculoskeletal Health : Diabetes and Musculoskeletal Health.Galen medical journal · 2025Review
- Review
- Romosozumab rescues impaired bone mass and strength in a murine model of diabetic kidney disease.Bone reports · 2024Article
- Biomechanics of the Human Osteochondral Unit: A Systematic Review.Materials (Basel, Switzerland) · 2024Review
- Potential Metabolic Pathways Involved in Osteoporosis and Evaluation of Fracture Risk in Individuals with Diabetes.BioMed research international · 2024Review
- Review
- Type 2 diabetes alters the viscoelastic behavior and macromolecular composition of vertebra.Bone reports · 2023Article
- Bone collagen quality in lumbar fusion patients: the association between volumetric bone mineral density and advanced glycation endproducts.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Structural role of osteocalcin and its modification in bone fracture.Applied physics reviews · 2023Article
- Dermal ultrasound measurements for bone quality assessment : An investigation of advanced glycation endproducts derived from confocal fluorescence microscopy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Effect of Diabetes on Tendon Structure and Function: Not Limited to Collagen Crosslinking.Journal of diabetes science and technology · 2023Article
- Accumulation of fluorescent advanced glycation end products and carboxymethyl-lysine in human cortical and trabecular bone.Bone reports · 2022Article
- Review
- One-Year Mean A1c of > 7% is Associated with Poor Bone Microarchitecture and Strength in Men with Type 2 Diabetes Mellitus.Calcified tissue international · 2022Article
- Influence of Metastatic Bone Lesion Type and Tumor Origin on Human Vertebral Bone Architecture, Matrix Quality, and Mechanical Properties.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Non-enzymatic glycation (NEG) and enzymatic biochemical processes create crosslinks that modify the extracellular matrix (ECM) and affect the turnover of bone tissue. Because NEG affects turnover and turnover at the local level affects microarchitecture and formation and removal of microdamage, we hypothesized that NEG in cancellous bone is heterogeneous and accounts partly for the contribution of microarchitecture and microdamage on bone fragility. Human trabecular bone cores from 23 donors were subjected to compression tests. Mechanically tested cores as well as an additional 19 cores were stained with lead-uranyl acetate and imaged to determine microarchitecture and measure microdamage. Post-yield mechanical properties were measured and damaged trabeculae were extracted from a subset of specimens and characterized for the morphology of induced microdamage. Tested specimens and extracted trabeculae were quantified for enzymatic and non-enzymatic crosslink content using a colorimetric assay and Ultra-high Performance Liquid Chromatography (UPLC). Results show that an increase in enzymatic crosslinks was beneficial for bone where they were associated with increased toughness and decreased microdamage. Conversely, bone with increased NEG required less strain to reach failure and were less tough. NEG heterogeneously modified trabecular microarchitecture where high amounts of NEG crosslinks were found in trabecular rods and with the mechanically deleterious form of microdamage (linear microcracks). The extent of NEG in tibial cancellous bone was the dominant predictor of bone fragility and was associated with changes in microarchitecture and microdamage.
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Registered trials
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