Evidence map›Paper›PMID 22514690›Full record

SynthesisPloS one2012

Association of sedentary behaviour with metabolic syndrome: a meta-analysis.

Charlotte L Edwardson, Trish Gorely, Melanie J Davies, Laura J Gray, Kamlesh Khunti, Emma G Wilmot, Thomas Yates, Stuart J H Biddle

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 236 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed, 16 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

236 citing papers in PubMed, 16 syntheses or guidelines pooled it, 530 citations in OpenAlex.

  1. Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025
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  12. Sedentary Behavior and Sleep Problems: a Systematic Review and Meta-Analysis.International journal of behavioral medicine · 2017
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  16. Associations between sedentary behaviour and physical activity in children and adolescents: a meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2014
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176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Charlotte L EdwardsonDiabetes Research Department, University Hospitals of Leicester, Leicester, United Kingdom. C.L.Edwardson2@lboro.ac.uk
Trish Gorely
Melanie J Davies
Laura J Gray
Kamlesh Khunti
Emma G Wilmot
Thomas Yates
Stuart J H Biddle
University of Leicester · GBLoughborough University · GB

Funding

Department of Health RP-DG-1210-10183Department of Health RP-PG-0606-1272
6 · The paper itself

Abstract

backgroundIn recent years there has been a growing interest in the relationship between sedentary behaviour (sitting) and health outcomes. Only recently have there been studies assessing the association between time spent in sedentary behaviour and the metabolic syndrome. The aim of this study is to quantify the association between sedentary behaviour and the metabolic syndrome in adults using meta-analysis. METHODOLOGY/PRINCIPAL

findingsMedline, Embase and the Cochrane Library were searched using medical subject headings and key words related to sedentary behaviours and the metabolic syndrome. Reference lists of relevant articles and personal databases were hand searched. Inclusion criteria were: (1) cross sectional or prospective design; (2) include adults ≥ 18 years of age; (3) self-reported or objectively measured sedentary time; and (4) an outcome measure of metabolic syndrome. Odds Ratio (OR) and 95% confidence intervals for metabolic syndrome comparing the highest level of sedentary behaviour to the lowest were extracted for each study. Data were pooled using random effects models to take into account heterogeneity between studies. Ten cross-sectional studies (n = 21393 participants), one high, four moderate and five poor quality, were identified. Greater time spent sedentary increased the odds of metabolic syndrome by 73% (OR 1.73, 95% CI 1.55-1.94, p<0.0001). There were no differences for subgroups of sex, sedentary behaviour measure, metabolic syndrome definition, study quality or country income. There was no evidence of statistical heterogeneity (I(2) = 0.0%, p = 0.61) or publication bias (Eggers test t = 1.05, p = 0.32).

conclusionsPeople who spend higher amounts of time in sedentary behaviours have greater odds of having metabolic syndrome. Reducing sedentary behaviours is potentially important for the prevention of metabolic syndrome.

Indexed as

Sedentary BehaviorAdultCross-Sectional StudiesFemaleHumansMaleMetabolic SyndromeMiddle AgedOdds RatioProspective StudiesYoung Adult

Identifiers

PMID22514690
PMCPMC3325927
OpenAlexW2136098791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.