ArticlePloS one2012
Insulin signaling as a mechanism underlying developmental plasticity: the role of FOXO in a nutritional polyphenism.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- From flower buds to bolls: how cotton reproductive structures shape boll weevil development, reproduction and survival.Pest management science · 2026Article
- Transcriptomic basis underlying the evolution of female horn plasticity in scarab beetles.Frontiers in zoology · 2026Article
- Effects of population density on immunity and reproduction in bean beetles Callosobruchus maculatus.Scientific reports · 2025Article
- Article
- Genome evolution and divergence in cis-regulatory architecture is associated with condition-responsive development in horned dung beetles.PLoS genetics · 2024Article
- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
- Gene regulatory networks underlying the development and evolution of plasticity in horned beetles.Current opinion in insect science · 2023Review
- Expression Analysis in a Dispersal-Fecundity Polyphenism Identifies Growth Regulators and Effectors.Integrative and comparative biology · 2022Article
- Insects Provide Unique Systems to Investigate How Early-Life Experience Alters the Brain and Behavior.Frontiers in behavioral neuroscience · 2021Review
- Nutrition-responsive gene expression and the developmental evolution of insect polyphenism.Nature ecology & evolution · 2020Article
- Complex Evolution of Insect Insulin Receptors and Homologous Decoy Receptors, and Functional Significance of Their Multiplicity.Molecular biology and evolution · 2020Article
- Expression profiling of winged- and wingless-destined pea aphid embryos implicates insulin/insulin growth factor signaling in morph differences.Evolution & development · 2020Article
- A specific type of insulin-like peptide regulates the conditional growth of a beetle weapon.PLoS biology · 2019Article
- Insulin signalling's role in mediating tissue-specific nutritional plasticity and robustness in the horn-polyphenic beetle Onthophagus taurus.Proceedings. Biological sciences · 2018Article
- Manipulation of insulin signaling phenocopies evolution of a host-associated polyphenism.Nature communications · 2018Article
- The evolution of relative trait size and shape: insights from the genitalia of dung beetles.Development genes and evolution · 2018Article
- Nutritional Regulation of Phenotypic Plasticity in a Solitary Bee (Hymenoptera: Megachilidae).Environmental entomology · 2017Article
- Hedgehog signaling enables nutrition-responsive inhibition of an alternative morph in a polyphenic beetle.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Ecological Trade-offs between Migration and Reproduction Are Mediated by the Nutrition-Sensitive Insulin-Signaling Pathway.International journal of biological sciences · 2016Article
- Insulin-Related Peptide 5 is Involved in Regulating Embryo Development and Biochemical Composition in Pea Aphid with Wing Polyphenism.Frontiers in physiology · 2016Article
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Authors and funding
2 authors.
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Abstract
We investigated whether insulin signaling, known to mediate physiological plasticity in response to changes in nutrition, also facilitates discrete phenotypic responses such as polyphenisms. We test the hypothesis that the gene FOXO--which regulates growth arrest under nutrient stress--mediates a nutritional polyphenism in the horned beetle, Onthophagus nigriventris. Male beetles in the genus Onthophagus vary their mating strategy with body size: large males express horns and fight for access to females while small males invest heavily in genitalia and sneak copulations with females. Given that body size and larval nutrition are linked, we predicted that 1) FOXO expression would differentially scale with body size (nutritional status) between males and females, and 2) manipulation of FOXO expression would affect the nutritional polyphenism in horns and genitalia. First, we found that FOXO expression varied with body size in a tissue- and sex-specific manner, being more highly expressed in the abdominal tissue of large (horned) males, in particular in regions associated with genitalia development. Second, we found that knockdown of FOXO through RNA-interference resulted in the growth of relatively larger copulatory organs compared to control-injected individuals and significant, albeit modest, increases in relative horn length. Our results support the hypothesis that FOXO expression in the abdominal tissue limits genitalia growth, and provides limited support for the hypothesis that FOXO regulates relative horn length through direct suppression of horn growth. Both results support the idea that tissue-specific FOXO expression may play a general role in regulating scaling relationships in nutritional polyphenisms by signaling traits to be relatively smaller.
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