ArticlePloS one2012
A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Near-Infrared Triggered Anion Transport Induces Cancer Cell Death.Angewandte Chemie (International ed. in English) · 2026Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Chloride Selective, Nonprotonophoric Ion Transport with Macrocyclic Halogen Bonding Anionophores.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Thiourea-Based Receptors for Anion Recognition and Signaling.ACS omega · 2024Article
- Transmembrane Transport of Bicarbonate by Anion Receptors.ChemPlusChem · 2022Review
- Recent Advances in Bioactive Artificial Ionophores.Chembiochem : a European journal of chemical biology · 2021Review
- A Novel Cyclic Mobile Transporter Can Induce Apoptosis by Facilitating Chloride Anion Transport into Cells.ACS omega · 2020Article
- Transmembrane anion transport mediated by halogen bonding and hydrogen bonding triazole anionophores.Chemical science · 2020Article
- Apoptosis-inducing activity of a fluorescent barrel-rosette MChemical science · 2020Article
- A highly-selective chloride microelectrode based on a mercuracarborand anion carrier.Scientific reports · 2019Article
- Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs.Chemical science · 2019Article
- Article
- Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis.British journal of pharmacology · 2019Article
- Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux.Cell death & disease · 2019Article
- Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia.Nature · 2019Article
- Article
- Anion Recognition by a Bioactive Diureidodecalin Anionophore: Solid-State, Solution, and Computational Studies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy.Frontiers in pharmacology · 2018Article
- Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia.Nature chemistry · 2016Article
- Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel.Journal of the American Chemical Society · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the gene-encoding cystic fibrosis transmembrane conductance regulator (CFTR) cause defective transepithelial transport of chloride (Cl(-)) ions and fluid, thereby becoming responsible for the onset of cystic fibrosis (CF). One strategy to reduce the pathophysiology associated with CF is to increase Cl(-) transport through alternative pathways. In this paper, we demonstrate that a small synthetic molecule which forms Cl(-) channels to mediate Cl(-) transport across lipid bilayer membranes is capable of restoring Cl(-) permeability in human CF epithelial cells; as a result, it has the potential to become a lead compound for the treatment of human diseases associated with Cl(-) channel dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.