ArticlePloS one2012
The crest phenotype in chicken is associated with ectopic expression of HOXC8 in cranial skin.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- A review of genetic variation underlying chicken phenotypic diversity.Poultry science · 2025Review
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- Skin regional specification and higher-orderScience advances · 2025Article
- Whole-Genome Sequencing for Identifying Candidate Genes Related to the Special Phenotypes of the Taihu Dianzi Pigeon.Animals : an open access journal from MDPI · 2024Article
- Dumbbell-shaped brains of Polish crested chickens as a model system for the evolution of novel brain morphologies.Journal of anatomy · 2023Article
- Large-scale detection and characterization of interchromosomal rearrangements in normozoospermic bulls using massive genotype and phenotype data sets.Genome research · 2023Article
- Identification of Genes Associated with Crest Cushion Development in the Chinese Crested Duck.Animals : an open access journal from MDPI · 2022Article
- Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer.EBioMedicine · 2022Article
- Uganda chicken genetic resources: I. phenotypic and production characteristics.Frontiers in genetics · 2022Article
- Comprehensive analysis of structural variants in chickens using PacBio sequencing.Frontiers in genetics · 2022Article
- Shifts in growth, but not differentiation, foreshadow the formation of exaggerated forms under chicken domestication.Proceedings. Biological sciences · 2021Article
- Article
- The crest phenotype in domestic chicken is caused by a 197 bp duplication in the intron of HOXC10.G3 (Bethesda, Md.) · 2021Article
- High Genetic Diversity but Absence of Population Structure in Local Chickens of Sri Lanka Inferred by Microsatellite Markers.Frontiers in genetics · 2021Article
- Parallel Genetic Origin of Foot Feathering in Birds.Molecular biology and evolution · 2020Article
- Article
- Whole-genome resequencing reveals genetic indels of feathered-leg traits in domestic chickens.Journal of genetics · 2019Article
- Genetic and Molecular Basis of Feather Diversity in Birds.Genome biology and evolution · 2018Review
- Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck.BMC genomics · 2018Article
- Genomic determinants of epidermal appendage patterning and structure in domestic birds.Developmental biology · 2017Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Crest phenotype is characterised by a tuft of elongated feathers atop the head. A similar phenotype is also seen in several wild bird species. Crest shows an autosomal incompletely dominant mode of inheritance and is associated with cerebral hernia. Here we show, using linkage analysis and genome-wide association, that Crest is located on the E22C19W28 linkage group and that it shows complete association to the HOXC-cluster on this chromosome. Expression analysis of tissues from Crested and non-crested chickens, representing 26 different breeds, revealed that HOXC8, but not HOXC12 or HOXC13, showed ectopic expression in cranial skin during embryonic development. We propose that Crest is caused by a cis-acting regulatory mutation underlying the ectopic expression of HOXC8. However, the identification of the causative mutation(s) has to await until a method becomes available for assembling this chromosomal region. Crest is unfortunately located in a genomic region that has so far defied all attempts to establish a contiguous sequence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.