ArticleFrontiers in microbiology2012
Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform.
Article in Frontiers in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 287 citations in OpenAlex.
- Effectiveness of antimicrobial photodynamic therapy in the treatment of peri-implantitis: systematic review and meta-analysis.Lasers in medical science · 2024Pooled it
- Efficacy of surgical methods for peri-implantitis: a systematic review and network meta-analysis.BMC oral health · 2023Pooled it
- A combination of photodynamic therapy and antimicrobial compounds to treat skin and mucosal infections: a systematic review.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2019Pooled it
- Immediate results of photodynamic therapy for the treatment of halitosis in adolescents: a randomized, controlled, clinical trial.Lasers in medical science · 2016Trial
- Trial
- Quercetin: A Light in the Fight Against MRSA.MicrobiologyOpen · 2026Article
- A Carboxyl-Functionalized Graphene Quantum Dot Coating for Catheters Effective Against Emerging Drug-ResistantJournal of fungi (Basel, Switzerland) · 2026Article
- The photodynamic inactivation in the control of the seafood zoonotic parasite, Anisakis sp.Parasitology research · 2026Article
- Comparison of PDT using a 660 nm laser and methylene blue vs. an 810 nm laser and indocyanine green on different Candida species - in vitro.Lasers in medical science · 2026Article
- From reactive oxygen to cancer cell death: the science behind photodynamic therapy.Lasers in medical science · 2025Review
- Impact of Light-Activated Nanocomposite with Erythrosine B onAntibiotics (Basel, Switzerland) · 2025Article
- Rose Bengal-Assisted Photodynamic Antimicrobial Therapy for Keratitis.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2025Article
- Review
- Blue-Light Photoactivated Curcumin-Loaded Chitosan Nanoparticles Prepared by Nanoprecipitation and Ionic Gelation: A Promising Approach for Antimicrobial Photodynamic Inactivation.ACS applied bio materials · 2025Article
- Transcriptomics Uncovers Key Genes for Photodynamic Killing on Trichosporon asahii Biofilms.Mycopathologia · 2025Article
- Proteomic and metabolomic profiling reveals the fungicidal mechanisms ofFrontiers in microbiology · 2025Article
- Use of Antimicrobial Photodynamic Therapy to Inactivate Multidrug-ResistantPharmaceutics · 2024Article
- Effect of Combination of Blue and Red Light with Terbinafine on Cell Viability and Reactive Oxygen Species in Human Keratinocytes: Potential Implications for Cutaneous Mycosis.International journal of molecular sciences · 2024Article
- Effects of photodynamic therapy using bisdemethoxycurcumin combined with melatonin or acetyl-melatonin on C. Albicans.Scientific reports · 2024Article
- Reduction of Multispecies Biofilms on an Acrylic Denture Base Model by Antimicrobial Photodynamic Therapy Mediated by Natural Photosensitizers.Pharmaceuticals (Basel, Switzerland) · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
Opportunistic fungal pathogens may cause superficial or serious invasive infections, especially in immunocompromised and debilitated patients. Invasive mycoses represent an exponentially growing threat for human health due to a combination of slow diagnosis and the existence of relatively few classes of available and effective antifungal drugs. Therefore systemic fungal infections result in high attributable mortality. There is an urgent need to pursue and deploy novel and effective alternative antifungal countermeasures. Photodynamic therapy (PDT) was established as a successful modality for malignancies and age-related macular degeneration but photodynamic inactivation has only recently been intensively investigated as an alternative antimicrobial discovery and development platform. The concept of photodynamic inactivation requires microbial exposure to either exogenous or endogenous photosensitizer molecules, followed by visible light energy, typically wavelengths in the red/near infrared region that cause the excitation of the photosensitizers resulting in the production of singlet oxygen and other reactive oxygen species that react with intracellular components, and consequently produce cell inactivation and death. Antifungal PDT is an area of increasing interest, as research is advancing (i) to identify the photochemical and photophysical mechanisms involved in photoinactivation; (ii) to develop potent and clinically compatible photosensitizers; (iii) to understand how photoinactivation is affected by key microbial phenotypic elements multidrug resistance and efflux, virulence and pathogenesis determinants, and formation of biofilms; (iv) to explore novel photosensitizer delivery platforms; and (v) to identify photoinactivation applications beyond the clinical setting such as environmental disinfectants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.