ArticleFrontiers in aging neuroscience2012
Sub-Regional Hippocampal Injury is Associated with Fornix Degeneration in Alzheimer's Disease.
Article in Frontiers in aging neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 139 citations in OpenAlex.
- Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer's disease.Human brain mapping · 2018Trial
- Synergistic effects of GFAP and Aβ42: Implications for white matter integrity and verbal memory across the cognitive spectrum.Brain, behavior, & immunity - health · 2024Article
- Fornix degeneration in risk factors of Alzheimer's disease, possible trigger of cognitive decline.Cerebral circulation - cognition and behavior · 2023Review
- Frontostriatal and limbic contributions to cognitive decline in Parkinson's disease.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2023Article
- Characterization of diffusion magnetic resonance imaging revealing relationships between white matter disconnection and behavioral disturbances in mild cognitive impairment: a systematic review.Frontiers in neuroscience · 2023Review
- Deep learning identifies brain structures that predict cognition and explain heterogeneity in cognitive aging.NeuroImage · 2022Article
- Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging.Frontiers in neuroscience · 2022Article
- Synergism between fornix microstructure and beta amyloid accelerates memory decline in clinically normal older adults.Neurobiology of aging · 2019Article
- Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition.Neurobiology of aging · 2018Article
- Education amplifies brain atrophy effect on cognitive decline: implications for cognitive reserve.Neurobiology of aging · 2018Article
- Microstructural Changes in Patients With Parkinson's Disease Comorbid With REM Sleep Behaviour Disorder and Depressive Symptoms.Frontiers in neurology · 2018Article
- Staging of amyloid β, t-tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Morphological and Microstructural Changes of the Hippocampus in Early MCI: A Study Utilizing the Alzheimer's Disease Neuroimaging Initiative Database.Journal of clinical neurology (Seoul, Korea) · 2017Article
- Heritability of white matter microstructure in late middle age: A twin study of tract-based fractional anisotropy and absolute diffusivity indices.Human brain mapping · 2017Article
- The differences of the precommissural and postcommissural fornix in the hippocampal location: a diffusion tensor tractography study.Neuroradiology · 2017Article
- Dysregulation of Autophagy, Mitophagy, and Apoptotic Genes in the Medial Temporal Lobe Cortex in an Ischemic Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2016Article
- Impaired fornix-hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis.Translational psychiatry · 2016Article
- Mammillary Bodies in Alzheimer's Disease: A Golgi and Electron Microscope Study.American journal of Alzheimer's disease and other dementias · 2016Article
- β-amyloid, hippocampal atrophy and their relation to longitudinal brain change in cognitively normal individuals.Neurobiology of aging · 2016Article
- Disruption of thalamic connectivity in Alzheimer's disease: a diffusion tensor imaging study.Metabolic brain disease · 2015Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
We examined in vivo evidence of axonal degeneration in association with neuronal pathology in Alzheimer's disease (AD) through analysis of fornix microstructural integrity and measures of hippocampal subfield atrophy. Based on known anatomical topography, we hypothesized that the local thickness of subiculum and CA1 hippocampus fields would be associated with fornix integrity, reflecting an association between AD-related injury to hippocampal neurons and degeneration of associated axon fibers. To test this hypothesis, multi-modal imaging, combining measures of local hippocampal radii with diffusion tensor imaging (DTI), was applied to 44 individuals clinically diagnosed with AD, 44 individuals clinically diagnosed with mild cognitive impairment (MCI), and 96 cognitively normal individuals. Fornix microstructural degradation, as measured by reduced DTI-based fractional anisotropy (FA), was prominent in both MCI and AD, and was associated with reduced hippocampal volumes. Further, reduced fornix FA was associated with reduced anterior CA1 and antero-medial subiculum thickness. Finally, while both lesser fornix FA and lesser hippocampal volume were associated with lesser episodic memory, only the hippocampal measures were significant predictors of episodic memory in models including both hippocampal and fornix predictors. The region-specific association between fornix integrity and hippocampal neuronal death may provide in vivo evidence for degenerative white matter injury in AD: axonal pathology that is closely linked to neuronal injury.
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