Evidence map›Paper›PMID 22514473›Full record

ArticleThe Canadian journal of infectious diseases = Journal canadien des maladies infectieuses1997

Decision analysis modelling of costs and outcomes following cefepime monotherapy in Canada.

M T Halpern, R E Brown, M Drolet, S V Sorensen, L A Mandell

Open access · hybridAbstract read
In one paragraph

Article in The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Medical decision analysis in infectious diseases.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 2000
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M T HalpernMEDTAP International, Bethesda, Maryland; Bristol-Myers Squibb, Montreal, Quebec; and Division of Infectious Diseases, McMaster University, Hamilton, Ontario.
R E Brown
M Drolet
S V Sorensen
L A Mandell
Bristol-Myers Squibb (Canada) · CAMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the comparative cost of treatment and intermediate outcomes (percentage resistant organisms, days in hospital, etc) among cefepime and alternative parenteral antibiotics used for empiric monotherapy.

designDecision analysis model, based on published literature, clinical trial results and information from infectious disease clinicians.

settingA Canadian tertiary care hospital.

interventionComparison of cefepime, ceftazidime, ceftriaxone, cefotaxime and ciprofloxacin in the treatment of lower respiratory tract infections, urinary tract infections, skin/soft tissue infections, septicemia and febrile neutropenia. MAIN

resultsCefepime treatment results in the lowest average cost per patient when used as initial empiric therapy for lower respiratory tract infections and for skin/soft tissue infections. Cefepime therapy is among the lowest cost treatments for the other infectious disease conditions and has the lowest cost for a weighted 'average' condition. Sensitivity analysis indicates that model results are most sensitive to duration of hospitalization.

conclusionsInitial empiric monotherapy with cefepime for serious infectious disease conditions may result in cost savings compared with alternative parenteral agents.

Indexed as

AntibioticsCefepimeCostsDecision analysisEconomic models

Identifiers

PMID22514473
PMCPMC3327332
OpenAlexW2329041800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.