ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Parallel coding of first- and second-order stimulus attributes by midbrain electrosensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 67 citations in OpenAlex.
- Electrosensory midbrain neurons optimally decode ascending input during object localization.The Journal of physiology · 2025Article
- Nonresponsive Neurons Improve Population Coding of Object Location.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Descending pathways increase sensory neural response heterogeneity to facilitate decoding and behavior.iScience · 2023Article
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- Synergistic population coding of natural communication stimuli by hindbrain electrosensory neurons.Scientific reports · 2021Article
- Population Coding of Natural Electrosensory Stimuli by Midbrain Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neuronal On- and Off-type heterogeneities improve population coding of envelope signals in the presence of stimulus-induced noise.Scientific reports · 2020Article
- Task-Related Sensorimotor Adjustments Increase the Sensory Range in Electrolocation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Serotonergic Modulation of Sensory Neuron Activity and Behavior inFrontiers in integrative neuroscience · 2020Article
- Neural Synchrony Gives Rise to Amplitude- and Duration-Invariant Encoding Consistent With Perception of Natural Communication Stimuli.Frontiers in neuroscience · 2020Article
- Descending pathways mediate adaptive optimized coding of natural stimuli in weakly electric fish.Science advances · 2019Article
- Encoding and Perception of Electro-communication Signals inFrontiers in integrative neuroscience · 2019Review
- Novel Functions of Feedback in Electrosensory Processing.Frontiers in integrative neuroscience · 2019Article
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- Descending pathways generate perception of and neural responses to weak sensory input.PLoS biology · 2018Article
- Population Coding and Correlated Variability in Electrosensory Pathways.Frontiers in integrative neuroscience · 2018Review
- Physiological evidence of sensory integration in the electrosensory lateral line lobe of Gnathonemus petersii.PloS one · 2018Article
- SK channel subtypes enable parallel optimized coding of behaviorally relevant stimulus attributes: A review.Channels (Austin, Tex.) · 2017Review
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Natural stimuli often have time-varying first-order (i.e., mean) and second-order (i.e., variance) attributes that each carry critical information for perception and can vary independently over orders of magnitude. Experiments have shown that sensory systems continuously adapt their responses based on changes in each of these attributes. This adaptation creates ambiguity in the neural code as multiple stimuli may elicit the same neural response. While parallel processing of first- and second-order attributes by separate neural pathways is sufficient to remove this ambiguity, the existence of such pathways and the neural circuits that mediate their emergence have not been uncovered to date. We recorded the responses of midbrain electrosensory neurons in the weakly electric fish Apteronotus leptorhynchus to stimuli with first- and second-order attributes that varied independently in time. We found three distinct groups of midbrain neurons: the first group responded to both first- and second-order attributes, the second group responded selectively to first-order attributes, and the last group responded selectively to second-order attributes. In contrast, all afferent hindbrain neurons responded to both first- and second-order attributes. Using computational analyses, we show how inputs from a heterogeneous population of ON- and OFF-type afferent neurons are combined to give rise to response selectivity to either first- or second-order stimulus attributes in midbrain neurons. Our study thus uncovers, for the first time, generic and widely applicable mechanisms by which parallel processing of first- and second-order stimulus attributes emerges in the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.