ArticleThe Journal of biological chemistry2012
Estrogen-induced expression of Fos-related antigen 1 (FRA-1) regulates uterine stromal differentiation and remodeling.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Fra-1 promotes gastric cancer progression by regulating macrophage polarization and transcriptionally activating HMGA2 expression.Cell death discovery · 2025Article
- Extracellular Vesicles Secreted by Mouse Decidual Cells Carry Critical Information for the Establishment of Pregnancy.Endocrinology · 2022Article
- A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Estrogen-induced FOS-like 1 regulates matrix metalloproteinase expression and the motility of human endometrial and decidual stromal cells.The Journal of biological chemistry · 2020Article
- Estrogen receptor alpha isoform ERdelta7 in myometrium modulates uterine quiescence during pregnancy.EBioMedicine · 2019Article
- Activator Protein-1 Transcriptional Activity Drives Soluble Micrograft-Mediated Cell Migration and Promotes the Matrix Remodeling Machinery.Stem cells international · 2019Article
- Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders.International journal of molecular sciences · 2018Review
- SULFATION PATHWAYS: A role for steroid sulphatase in intracrine regulation of endometrial decidualisation.Journal of molecular endocrinology · 2018Review
- The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases.International journal of biological sciences · 2018Review
- Inhibition of MMP-9 expression by ritonavir or saquinavir is associated with inactivation of the AKT/Fra-1 pathway in cervical intraepithelial neoplasia cells.Oncology letters · 2017Article
- Serum Response Factor Protects Retinal Ganglion Cells Against High-Glucose Damage.Journal of molecular neuroscience : MN · 2016Article
- Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice.Endocrinology · 2016Article
- Physiological and molecular determinants of embryo implantation.Molecular aspects of medicine · 2013Review
- Uterine micro-environment and estrogen-dependent regulation of osteopontin expression in mouse blastocyst.International journal of molecular sciences · 2013Article
- WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal cell differentiation.Endocrinology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Concerted actions of estrogen and progesterone via their cognate receptors orchestrate changes in the uterine tissue, regulating implantation during early pregnancy. The uterine stromal cells undergo steroid-dependent differentiation into morphologically and functionally distinct decidual cells, which support embryonic growth and survival. The hormone-regulated pathways underlying this unique cellular transformation are not fully understood. Previous studies in the mouse revealed that, following embryo attachment, de novo synthesis of estrogen by the decidual cells is critical for stromal differentiation. In this study we report that Fos-related antigen 1 (FRA-1), a member of the Fos family of transcription factors, is a downstream target of regulation by intrauterine estrogen. FRA-1 expression was localized in the differentiating uterine stromal cells surrounding the implanted embryo. Attenuation of estrogen receptor α (Esr1) expression by siRNA mediated silencing in primary uterine stromal cells suppressed FRA-1 expression. Furthermore, chromatin immunoprecipitation demonstrated direct recruitment of ESR1 to an estrogen response element in the Fra-1 promoter. Down-regulation of Fra-1 expression during in vitro decidualization blocked stromal differentiation and resulted in a marked decrease in stromal cell migration. Interestingly, FRA-1 controls the expression of matrix metalloproteinases MMP9 and MMP13, which are critical modulators of stromal extracellular matrix remodeling. Collectively, these results suggest that FRA-1, induced in response to estrogen signaling via ESR1, is a key regulator of stromal differentiation and remodeling during early pregnancy.
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