ReviewTrends in amplification2012
Stem cell therapy for the inner ear: recent advances and future directions.
Review in Trends in amplification, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 96 citations in OpenAlex.
- Can Stem Cells Restore Hearing? A Narrative Review Exploring Regenerative Medicine for Congenital Hearing Loss.Journal of otology · 2025Review
- The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Review
- A combinatorial approach to protect sensory tissue against cisplatin-induced ototoxicity.Hearing research · 2022Article
- [Research advances on umbilical cord blood derived mesenchymal stem cell in therapy of sensorineural hearing loss].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Review
- Usher Syndrome: Genetics and Molecular Links of Hearing Loss and Directions for Therapy.Frontiers in genetics · 2020Review
- Imaging hair cells through laser-ablated cochlear bone.Biomedical optics express · 2019Article
- Gene therapy for hearing loss.Human molecular genetics · 2019Review
- Hearing regeneration and regenerative medicine: present and future approaches.Archives of medical science : AMS · 2019Article
- Pluripotent stem cell-derived cochlear cells: a challenge in constant progress.Cellular and molecular life sciences : CMLS · 2019Review
- Innovative pharmaceutical approaches for the management of inner ear disorders.Drug delivery and translational research · 2018Review
- A drop array culture for patterning adherent mouse embryonic stem cell-derived neurospheres.Journal of tissue engineering and regenerative medicine · 2018Article
- Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium.Scientific reports · 2017Article
- A Simple Model for Inducing Optimal Increase ofBioMed research international · 2017Article
- Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles.PloS one · 2017Article
- Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation.Cell death and differentiation · 2016Article
- Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells.Journal of visualized experiments : JoVE · 2016Article
- Epigenetic DNA Demethylation Causes Inner Ear Stem Cell Differentiation into Hair Cell-Like Cells.Frontiers in cellular neuroscience · 2016Article
- Stem Cell Therapy for Sensorineural Hearing Loss, Still Alive?Journal of audiology & otology · 2015Review
- New treatment options for hearing loss.Nature reviews. Drug discovery · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In vertebrates, perception of sound, motion, and balance is mediated through mechanosensory hair cells located within the inner ear. In mammals, hair cells are only generated during a short period of embryonic development. As a result, loss of hair cells as a consequence of injury, disease, or genetic mutation, leads to permanent sensory deficits. At present, cochlear implantation is the only option for profound hearing loss. However, outcomes are still variable and even the best implant cannot provide the acuity of a biological ear. The recent emergence of stem cell technology has the potential to open new approaches for hair cell regeneration. The goal of this review is to summarize the current state of inner ear stem cell research from a viewpoint of its clinical application for inner ear disorders to illustrate how complementary studies have the potential to promote and refine stem cell therapies for inner ear diseases. The review initially discusses our current understanding of the genetic pathways that regulate hair cell formation from inner ear progenitors during normal development. Subsequent sections discuss the possible use of endogenous inner ear stem cells to induce repair as well as the initial studies aimed at transplanting stem cells into the ear.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.