ArticleJournal of the Royal Society, Interface2012
Competition-colonization trade-off promotes coexistence of low-virulence viral strains.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Analysis of the competition among viral strains using a temporal interaction-driven contagion model.Scientific reports · 2022Article
- Antagonistic within-host interactions between plant viruses: molecular basis and impact on viral and host fitness.Molecular plant pathology · 2016Review
- Differential Persistence of Foot-and-Mouth Disease Virus in African Buffalo Is Related to Virus Virulence.Journal of virology · 2016Article
- Competition, virulence, host body mass and the diversification of macro-parasites.Journal of the Royal Society, Interface · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA viruses exist as genetically diverse populations displaying a range of virulence degrees. The evolution of virulence in viral populations is, however, poorly understood. On the basis of the experimental observation of an RNA virus clone in cell culture diversifying into two subpopulations of different virulence, we study the dynamics of mutating virus populations with varying virulence. We introduce a competition-colonization trade-off into standard mathematical models of intra-host viral infection. Colonizers are fast-spreading virulent strains, whereas the competitors are less-virulent variants but more successful within co-infected cells. We observe a two-step dynamics of the population. Early in the infection, the population is dominated by colonizers, which later are outcompeted by competitors. Our simulations suggest the existence of steady state in which all virulence classes coexist but are dominated by the most competitive ones. This equilibrium implies collective virulence attenuation in the population, in contrast to previous models predicting evolution of the population towards increased virulence.
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