ArticleDiseases of the colon and rectum2012
Population-based evaluation of adenosquamous carcinoma of the colon and rectum.
Article in Diseases of the colon and rectum, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 70 citations in OpenAlex.
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- Clinicopathological and molecular characteristics of colorectal adenosquamous carcinoma in an Asian population.BMC gastroenterology · 2024Article
- A novel risk model for predicting peritoneal metastasis in colorectal cancer based on the SEER database.Journal of cancer research and clinical oncology · 2023Article
- New Histoprognostic Factors to Consider for the Staging of Colon Cancers: Tumor Deposits, Invasive Tumor Infiltration and High-Grade Budding.International journal of molecular sciences · 2023Article
- Heterotopic ossification in primary rectal cancer with squamous cell carcinoma-like differentiation.Fujita medical journal · 2022Article
- A "conversion-deterioration-double mutation" theory for the evolution and progression of colorectal cancer.Cancer medicine · 2022Review
- Loss of CDX2 in colorectal cancer is associated with histopathologic subtypes and microsatellite instability but is prognostically inferior to hematoxylin-eosin-based morphologic parameters from the WHO classification.British journal of cancer · 2021Article
- Atypical Expression of CK7 and CK20 in Adenosquamous Carcinoma, Colon-a Rare Case.Journal of gastrointestinal cancer · 2021Article
- Adenosquamous carcinoma of the hepatic flexure of colon: a case report.Translational cancer research · 2021Article
- A population-based analysis of adenosquamous carcinoma of the salivary gland.Gland surgery · 2021Article
- Survival and risk factors of adenosquamous carcinoma in the oral and maxillofacial region: a population-based study.American journal of translational research · 2021Article
- Primary adenosquamous carcinoma of the liver detected during cancer surveillance in a patient with primary sclerosing cholangitis.Clinical journal of gastroenterology · 2020Article
- Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.International journal of colorectal disease · 2020Article
- [Successful pembrolizumab therapy in metastasized adenosquamous carcinoma of the colon].Der Pathologe · 2019Article
- Review
- A case of locally advanced adenosquamous carcinoma of the cecum with long-term survival.Fujita medical journal · 2019Article
- Adenosquamous Carcinoma of the Stomach: A Population-based Study from the SEER Database.Journal of Cancer · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInformation about adenosquamous carcinoma of the colon and rectum is scarce because of its extremely low incidence.
objectiveThe aim of this study was to examine the prognostic significance of a histological diagnosis of adenosquamous carcinoma in comparison with adenocarcinoma of the colon and rectum.
designThis study was retrospective in design.
settingCalifornia Cancer Registry data from 1994 through 2004 with follow-up through 2008 were analyzed. PATIENTS: Patients were included whose cancer of the colon and rectum, excluding the anus with a tumor histology of adenocarcinoma and adenosquamous carcinoma, was surgically treated.
main outcome measuresThe primary outcomes measured were histology-specific survival analyses (with the use of the Kaplan-Meier method), and overall and colorectal-specific mortality (with the use of multivariable Cox proportional hazards regression analyses).
resultsA total of 111,263 adenocarcinoma and adenosquamous carcinoma of colon and rectal cancer cases were identified (adenocarcinoma, 99.91%; adenosquamous carcinoma, 0.09%). There was no significant difference in sex, age, race, and socioeconomic status between the 2 groups. The most common location of adenocarcinoma and adenosquamous carcinoma was the right and transverse colon. The adenosquamous carcinoma group was significantly associated with a higher rate of metastasis at the time of operation (adenosquamous carcinoma, 36.56% vs adenocarcinoma, 13.92%) and with poorly differentiated tumor grade (adenosquamous carcinoma, 65.96% vs adenocarcinoma, 19.74%) in comparison with the adenocarcinoma group. The median overall survival time was significantly greater in the adenocarcinoma group (82.4 months) in comparison with the adenosquamous carcinoma group (35.3 months). With the use of multivariable hazard regression analyses, adenosquamous carcinoma histology was independently associated with increased overall mortality (hazard ratio, 1.67) and colorectal-specific mortality (hazard ratio, 1.69) in comparison with adenocarcinoma.
conclusionsThis is one of the largest studies of adenosquamous carcinoma of the colon and rectum to date. This uncommon colorectal cancer subtype was associated with higher overall and colorectal-specific mortality in comparison with adenocarcinoma. Among colorectal cancer cases, adenosquamous carcinoma histology should be considered a poor prognostic feature.
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