ArticleThe Journal of general virology2012
The small genome segment of Bunyamwera orthobunyavirus harbours a single transcription-termination signal.
Article in The Journal of general virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- The La Crosse virus M segment determines virus isolate cell-to-cell spread and virulence.bioRxiv : the preprint server for biology · 2026Article
- Conserved non-coding RNA motifs influence the neuropathogenicity of Simbuviruses: Molecular dissection in the Schmallenberg virus model.PLoS pathogens · 2026Article
- Structural characterization of the full-length Hantaan virus polymerase.PLoS pathogens · 2024Article
- The mechanism of genome replication and transcription in bunyaviruses.PLoS pathogens · 2023Review
- Article
- Mosquito-borne Inkoo virus in northern Sweden - isolation and whole genome sequencing.Virology journal · 2017Article
- Generation of a Recombinant Akabane Virus Expressing Enhanced Green Fluorescent Protein.Journal of virology · 2015Article
- Flexibility of bunyavirus genomes: creation of an orthobunyavirus with an ambisense S segment.Journal of virology · 2015Article
- Orthobunyaviruses: recent genetic and structural insights.Nature reviews. Microbiology · 2014Review
- Attenuation of bunyamwera orthobunyavirus replication by targeted mutagenesis of genomic untranslated regions and creation of viable viruses with minimal genome segments.Journal of virology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transcription termination of the mRNA produced from the small (S) genome segment of Bunyamwera orthobunyavirus (BUNV) has previously been mapped to two cis-acting sequences located within the 5' UTR using a virus-free replication assay. The ability of these sequences to terminate transcription was attributed to the shared pentanucleotide motif 3'-UGUCG-5'. Taking advantage of our plasmid-based rescue system to generate recombinant viruses, we re-evaluated the importance of both pentanucleotide motifs as well as that of two other conserved sequences in transcription termination in vivo. Analysis of the 3' ends of positive-stranded viral RNAs derived from the S segment revealed that only the region around the upstream pentanucleotide motif mediated transcription termination in cells infected with wild-type BUNV, leading to mRNAs that were about 100 nt shorter than antigenome RNA. Furthermore, the downstream motif was not recognized in recombinant viruses in which the upstream signal has been disrupted. Our results suggest that in the context of virus infection transcription termination of the BUNV S genome segment mRNA is exclusively directed by the upstream-termination signal. Interestingly, within this region we identified a motif similar to a transcription-termination sequence used by Rift Valley fever phlebovirus.
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