ArticleDevelopment (Cambridge, England)2012
The floral homeotic protein APETALA2 recognizes and acts through an AT-rich sequence element.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 108 citations in OpenAlex.
- Genome-wide analysis of the AP2 transcription factor family in cultivated sugarcane reveals ShAP2-1 as an enhancer of drought tolerance.BMC plant biology · 2026Article
- Co-transcriptional gene regulation in plants.aBIOTECH · 2026Review
- Dynamic Transcriptome Profiling Reveals Key Regulatory Networks Underlying Curd Development in Cauliflower (International journal of molecular sciences · 2026Article
- Post-Translational Modifications of TOE3 Regulate Antiviral Defense in Tobacco.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Comparative genome-wide characterization and evolutionary insights into the AP2/ERF gene family in three Coffea species (C. canephora, C. eugenioides, and C. arabica).BMC genomics · 2025Article
- Molecular regulation and domestication of parthenocarpy in cucumber.Nature plants · 2025Article
- Functional Studies on thePlants (Basel, Switzerland) · 2025Article
- Identification and characterization of two APETALA2 homolog genes in lotus (Nelumbo nucifera) involved in sepal and petal development.BMC plant biology · 2024Article
- APETALA2-like Floral Homeotic Protein Up-RegulatingInternational journal of molecular sciences · 2024Article
- The APETALA2-MYBL2 module represses proanthocyanidin biosynthesis by affecting formation of the MBW complex in seeds of Arabidopsis thaliana.Plant communications · 2024Article
- Time-Course Transcriptomic Analysis Reveals Molecular Insights into the Inflorescence and Flower Development ofPlants (Basel, Switzerland) · 2024Article
- Characterization of TwoPlants (Basel, Switzerland) · 2023Article
- Transcription factor induction of vascular blood stem cell niches in vivo.Developmental cell · 2023Article
- Article
- Antagonistic regulation of target genes by the SISTER OF TM3-JOINTLESS2 complex in tomato inflorescence branching.The Plant cell · 2023Article
- Advances of Apetala2/Ethylene Response Factors in Regulating Development and Stress Response in Maize.International journal of molecular sciences · 2023Review
- An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression.Nature communications · 2022Article
- FaesAP3_1 Regulates theInternational journal of molecular sciences · 2022Article
- Characterization ofPlants (Basel, Switzerland) · 2022Article
- A banana transcriptional repressor MaAP2a participates in fruit starch degradation during postharvest ripening.Frontiers in plant science · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Cell fate specification in development requires transcription factors for proper regulation of gene expression. In Arabidopsis, transcription factors encoded by four classes of homeotic genes, A, B, C and E, act in a combinatorial manner to control proper floral organ identity. The A-class gene APETALA2 (AP2) promotes sepal and petal identities in whorls 1 and 2 and restricts the expression of the C-class gene AGAMOUS (AG) from whorls 1 and 2. However, it is unknown how AP2 performs these functions. Unlike the other highly characterized floral homeotic proteins containing MADS domains, AP2 has two DNA-binding domains referred to as the AP2 domains and its DNA recognition sequence is still unknown. Here, we show that the second AP2 domain in AP2 binds a non-canonical AT-rich target sequence, and, using a GUS reporter system, we demonstrate that the presence of this sequence in the AG second intron is important for the restriction of AG expression in vivo. Furthermore, we show that AP2 binds the AG second intron and directly regulates AG expression through this sequence element. Computational analysis reveals that the binding site is highly conserved in the second intron of AG orthologs throughout Brassicaceae. By uncovering a biologically relevant AT-rich target sequence, this work shows that AP2 domains have wide-ranging target specificities and provides a missing link in the mechanisms that underlie flower development. It also sets the foundation for understanding the basis of the broad biological functions of AP2 in Arabidopsis, as well as the divergent biological functions of AP2 orthologs in dicotyledonous plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.