Trial reportBreast cancer research : BCR2012
Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers.
Trial report in Breast cancer research : BCR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Mammographic density and breast cancer pathological subtypes by menopausal status and body mass index.Breast cancer research : BCR · 2025Article
- Associations of perfluoroalkyl substances (PFAS) with terminal ductal lobular unit involution of the normal breast.Breast cancer research : BCR · 2025Article
- Associations of Stem Cell Markers with Lobular Involution in Benign Breast Tissue.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Risk factors for breast cancer subtypes by race and ethnicity: a scoping review.Journal of the National Cancer Institute · 2024Article
- Associations between quantitative measures of mammographic density and terminal ductal lobular unit involution in Chinese breast cancer patients.Breast cancer research : BCR · 2024Article
- Risk factors for breast cancer subtypes by race and ethnicity: A scoping review of the literature.medRxiv : the preprint server for health sciences · 2024Article
- Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era.JAMA surgery · 2024Article
- Host, reproductive, and lifestyle factors in relation to quantitative histologic metrics of the normal breast.Breast cancer research : BCR · 2023Article
- Associations between quantitative measures of TDLU involution and breast tumor molecular subtypes among breast cancer cases in the Black Women's Health Study: a case-case analysis.Breast cancer research : BCR · 2022Article
- Association of Genetic Ancestry With Terminal Duct Lobular Unit Involution Among Healthy Women.Journal of the National Cancer Institute · 2022Article
- Deep Learning Image Analysis of Benign Breast Disease to Identify Subsequent Risk of Breast Cancer.JNCI cancer spectrum · 2021Article
- Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?International journal of molecular sciences · 2020Review
- Automated Quantitative Measures of Terminal Duct Lobular Unit Involution and Breast Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy.Journal of clinical medicine · 2020Article
- Deep learning assessment of breast terminal duct lobular unit involution: Towards automated prediction of breast cancer risk.PloS one · 2020Article
- Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast.NPJ breast cancer · 2020Article
- Involution of Breast Lobules, Mammographic Breast Density and Prognosis Among Tamoxifen-Treated Estrogen Receptor-Positive Breast Cancer Patients.Journal of clinical medicine · 2019Article
- Stroma modifies relationships between risk factor exposure and age-related epithelial involution in benign breast.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Age-related terminal duct lobular unit involution in benign tissues from Chinese breast cancer patients with luminal and triple-negative tumors.Breast cancer research : BCR · 2017Article
- Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis.Breast cancer research : BCR · 2017Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
introductionInvolution of terminal duct lobular units (TDLUs), the structures that give rise to most breast cancers, has been associated with reduced breast cancer risk. Data suggest that the etiology and pathogenesis of luminal A and core basal phenotype (CBP) breast cancers differ, but associations with TDLU involution are unknown. Accordingly, we performed a masked microscopic assessment of TDLU involution in benign tissues associated with luminal A and CBP breast cancers diagnosed among women less than age 55 years.
methodsCases were participants in a population-based case-control study conducted in Poland. Increased TDLU involution was defined as fewer acini per TDLU or shorter TDLU diameter. Luminal A was defined as estrogen receptor (ER) positive and/or progesterone receptor (PR) positive and human epidermal growth factor receptor 2 (HER2) negative and CBP as negative for ER, PR, and HER2 with expression of basal cytokeratins or epidermal growth factor receptor (EGFR). We performed logistic regression to evaluate associations between TDLU involution and tumor subtypes, adjusted for clinical characteristics and breast cancer risk factors.
resultsAmong 232 luminal A and 49 CBP cancers associated with evaluable TDLUs, CBP tumors were associated with significantly greater average number of acini per TDLU (odds ratio (OR) = 3.36, 95% confidence interval (CI) = 1.36 to 8.32, P = 0.009) and larger average TDLU diameter (OR = 2.49, 95% CI = 1.08 to 5.74, P = 0.03; comparing highest to lowest group, adjusted for age and study site).
conclusionsWe suggest that TDLU involution is less marked in benign tissues surrounding CBP as compared to luminal A cancers, which may reflect differences in the etiology and pathogenesis of these tumor subtypes.
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