ArticleMolecular biology and evolution2012
Ancient structure in Africa unlikely to explain Neanderthal and non-African genetic similarity.
Article in Molecular biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- Ignoring population structure in hominin evolutionary models can lead to the inference of spurious admixture events.Nature ecology & evolution · 2025Article
- Article
- Haplotype-Based Approach Represents Locus Specificity in the Genomic Diversification Process in Humans (Genes · 2024Review
- Inference of Locus-Specific Population Mixtures from Linked Genome-Wide Allele Frequencies.Molecular biology and evolution · 2024Article
- Temporal population structure, a genetic dating method for ancient Eurasian genomes from the past 10,000 years.Cell reports methods · 2022Article
- Phylogenetics in space: How continuous spatial structure impacts tree inference.Molecular phylogenetics and evolution · 2022Review
- Inferring archaic introgression from hominin genetic data.Evolutionary anthropology · 2021Review
- Origins of modern human ancestry.Nature · 2021Review
- Signatures of Introgression across the Allele Frequency Spectrum.Molecular biology and evolution · 2021Article
- Signals interpreted as archaic introgression appear to be driven primarily by faster evolution in Africa.Royal Society open science · 2020Article
- Recovering signals of ghost archaic introgression in African populations.Science advances · 2020Article
- Article
- Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.Cell · 2019Article
- Article
- Variation and Functional Impact of Neanderthal Ancestry in Western Asia.Genome biology and evolution · 2017Article
- Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation.Molecular biology and evolution · 2017Article
- Distinguishing recent admixture from ancestral population structure.Genome biology and evolution · 2017Article
- IBD Sharing between Africans, Neandertals, and Denisovans.Genome biology and evolution · 2016Article
- Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.Genome biology · 2016Article
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4 authors.
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Abstract
Neanderthals have been shown to share more genetic variants with present-day non-Africans than Africans. Recent admixture between Neanderthals and modern humans outside of Africa was proposed as the most parsimonious explanation for this observation. However, the hypothesis of ancient population structure within Africa could not be ruled out as an alternative explanation. We use simulations to test whether the site frequency spectrum, conditioned on a derived Neanderthal and an ancestral Yoruba (African) nucleotide (the doubly conditioned site frequency spectrum [dcfs]), can distinguish between models that assume recent admixture or ancient population structure. We compare the simulations to the dcfs calculated from data taken from populations of European, Chinese, and Japanese descent in the Complete Genomics Diversity Panel. Simulations under a variety of plausible demographic parameters were used to examine the shape of the dcfs for both models. The observed shape of the dcfs cannot be explained by any set of parameter values used in the simulations of the ancient structure model. The dcfs simulations for the recent admixture model provide a good fit to the observed dcfs for non-Africans, thereby supporting the hypothesis that recent admixture with Neanderthals accounts for the greater similarity of Neanderthals to non-Africans than Africans.
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