ArticleMicrobial biotechnology2013
Glycerol as a substrate for aerobic succinate production in minimal medium with Corynebacterium glutamicum.
Article in Microbial biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- Sustainable production of glutaric acid in microbial cell factories: Current advances and future prospects.Synthetic and systems biotechnology · 2026Review
- Consolidated bioprocessing of inulin-containing feedstock to succinic acid by newly isolatedBiotechnology reports (Amsterdam, Netherlands) · 2025Article
- Physiological characteristics of Corynebacterium glutamicum as a cell factory under anaerobic conditions.Applied microbiology and biotechnology · 2021Review
- Diverse Profile of Fermentation Byproducts From Thin Stillage.Frontiers in bioengineering and biotechnology · 2021Article
- Boosting Escherichia coli's heterologous production rate of ectoines by exploiting the non-halophilic gene cluster from Acidiphilium cryptum.Extremophiles : life under extreme conditions · 2020Article
- Article
- High-yield production of L-serine from glycerol by engineered Escherichia coli.Journal of industrial microbiology & biotechnology · 2019Article
- A new genome-scale metabolic model ofBiotechnology for biofuels · 2017Article
- Engineered biosynthesis of biodegradable polymers.Journal of industrial microbiology & biotechnology · 2016Review
- Toward glycerol biorefinery: metabolic engineering for the production of biofuels and chemicals from glycerol.Biotechnology for biofuels · 2016Review
- Metabolic engineering of Mortierella alpina for arachidonic acid production with glycerol as carbon source.Microbial cell factories · 2015Article
- Recent advances in the metabolic engineering of Corynebacterium glutamicum for the production of lactate and succinate from renewable resources.Journal of industrial microbiology & biotechnology · 2015Review
- Complex regulation of the phosphoenolpyruvate carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum.Journal of bacteriology · 2013Article
- Accelerated pentose utilization by Corynebacterium glutamicum for accelerated production of lysine, glutamate, ornithine and putrescine.Microbial biotechnology · 2013Article
- Bio-based production of organic acids with Corynebacterium glutamicum.Microbial biotechnology · 2013Review
- Two-component signal transduction in Corynebacterium glutamicum and other corynebacteria: on the way towards stimuli and targets.Applied microbiology and biotechnology · 2012Review
- Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products.Computational and structural biotechnology journal · 2012Review
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corynebacterium glutamicum, an established microbial cell factory for the biotechnological production of amino acids, was recently genetically engineered for aerobic succinate production from glucose in minimal medium. In this work, the corresponding strains were transformed with plasmid pVWEx1-glpFKD coding for glycerol utilization genes from Escherichia coli. This plasmid had previously been shown to allow growth of C. glutamicum with glycerol as sole carbon source. The resulting strains were tested in minimal medium for aerobic succinate production from glycerol, which is a by-product in biodiesel synthesis. The best strain BL-1/pVWEx1-glpFKD formed 79 mM (9.3 g l(-1)) succinate from 375 mM glycerol, representing 42% of the maximal theoretical yield under aerobic conditions. A specific succinate production rate of 1.55 mmol g(-1) (cdw) h(-1) and a volumetric productivity of 3.59 mM h(-1) were obtained, the latter value representing the highest one currently described in literature. The results demonstrate that metabolically engineered strains of C. glutamicum are well suited for aerobic succinate production from glycerol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.