ArticleBrain research2012
Longitudinal in-vivo diffusion tensor imaging for assessing brain developmental changes in BALB/cJ mice, a model of reduced sociability relevant to autism.
Article in Brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Emerging behavioral and neuroimaging biomarkers for early and accurate characterization of autism spectrum disorders: a systematic review.Translational psychiatry · 2021Pooled it
- MALDI Imaging Mass Spectrometry Visualizes the Distribution of Antidepressant Duloxetine and Its Major Metabolites in Mouse Brain, Liver, Kidney, and Spleen Tissues.Drug metabolism and disposition: the biological fate of chemicals · 2024Article
- Translational Magnetic Resonance Imaging in Autism Spectrum Disorder From the Mouse Model to Human.Frontiers in neuroscience · 2022Review
- Mapping the living mouse brain neural architecture: strain-specific patterns of brain structural and functional connectivity.Brain structure & function · 2021Article
- Awake functional MRI detects neural circuit dysfunction in a mouse model of autism.Science advances · 2020Article
- Severe white matter damage in SHANK3 deficiency: a human and translational study.Annals of clinical and translational neurology · 2020Article
- Convergent microstructural brain changes across genetic models of autism spectrum disorder-A pilot study.Psychiatry research. Neuroimaging · 2019Article
- The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes inMolecular autism · 2019Article
- Age-related differences in autism: The case of white matter microstructure.Human brain mapping · 2017Article
- Diffusion Tensor Imaging for Assessing Brain Gray and White Matter Abnormalities in a Feline Model of α-Mannosidosis.Journal of neuropathology and experimental neurology · 2016Article
- Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Neuroimaging endophenotypes in animal models of autism spectrum disorders: lost or found in translation?Psychopharmacology · 2014Review
- Sociosexual and communication deficits after traumatic injury to the developing murine brain.PloS one · 2014Article
- Article
- Novel inter-hemispheric white matter connectivity in the BTBR mouse model of autism.Brain research · 2013Article
- Neuroanatomical analysis of the BTBR mouse model of autism using magnetic resonance imaging and diffusion tensor imaging.NeuroImage · 2013Article
- Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice.Behavioural brain research · 2013Article
- MR diffusion tensor imaging detects rapid microstructural changes in amygdala and hippocampus following fear conditioning in mice.PloS one · 2013Article
- Co-expression profiling of autism genes in the mouse brain.PLoS computational biology · 2013Article
- Fast diffusion tensor magnetic resonance imaging of the mouse brain at ultrahigh-field: aiming at cohort studies.PloS one · 2012Article
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9 authors.
Funding
Abstract
Diffusion tensor imaging (DTI) is highly sensitive in detecting brain structure and connectivity phenotypes in autism spectrum disorders (ASD). Since one of the core symptoms of ASD is reduced sociability (reduced tendency to seek social interaction), we hypothesized that DTI will be sensitive in detecting neural phenotypes that correlate with decreased sociability in mouse models. Relative to C57BL/6J (B6) mice, juvenile BALB/cJ mice show reduced sociability. We performed social approach test in a three-chambered apparatus and in-vivo longitudinal DTI at post-natal days 30, 50 and 70 days-of-age in BALB/cJ (n=32) and B6 (n=15) mice to assess the correlation between DTI and sociability and to evaluate differences in DTI parameters between these two strains. Fractional anisotropy (FA) and mean diffusivity (MD) values from in-vivo DTI data were analyzed from white matter (corpus callosum, internal and external capsule) and gray matter (cerebral cortex, frontal motor cortex, hippocampus, thalamus and amygdaloid) regions based on their relevance to ASD. A moderate but significant (p<0.05) negative correlation between sociability and FA in hippocampus and frontal motor cortex was noted for BALB/cJ mice at 30 days-of-age. Significant differences in FA and MD values between BALB/cJ and B6 mice were observed in most white and gray matter areas at all three time points. Significant differences in developmental trajectories of FA and MD values from thalamus and frontal motor cortex were also observed between BALB/cJ and B6, indicating relative under-connectivity in BALB/cJ mice. These results indicate that DTI may be used as an in-vivo, non-invasive imaging method to assess developmental trajectories of brain connectivity in mouse models of neurodevelopmental and behavioral disorders.
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