ReviewBrain research2012
Understanding tinnitus: the dorsal cochlear nucleus, organization and plasticity.
Review in Brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Personalized Music-Embedded Sound Therapy Based on Gating Modulation and Neural Decoupling Reduces Tinnitus Severity.Brain sciences · 2026Article
- On the role of L-type Ca2+ and BK channels in a biophysical model of cartwheel interneurons.PLoS computational biology · 2026Article
- Potential therapeutic role of calcitonin gene-related peptide medications for tinnitus.Journal of the Chinese Medical Association : JCMA · 2026Review
- Identification and quantification of GABAIBRO neuroscience reports · 2025Article
- Could DTI Unlock the Mystery of Subjective Tinnitus: It's Time for Parameters That Go A Little Out of the Routine.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Lack of Amino Acid Alterations Within the Cochlear Nucleus and the Auditory Cortex in Acoustic Trauma-Induced Tinnitus Rats Using In Vivo Microdialysis.Audiology research · 2024Article
- Massive perturbation of sound representations by anesthesia in the auditory brainstem.Science advances · 2024Article
- Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum.International journal of molecular sciences · 2023Review
- Decreasing dorsal cochlear nucleus activity ameliorates noise-induced tinnitus perception in mice.BMC biology · 2022Article
- Intrinsic Noise Improves Speech Recognition in a Computational Model of the Auditory Pathway.Frontiers in neuroscience · 2022Article
- Tinnitus-like "hallucinations" elicited by sensory deprivation in an entropy maximization recurrent neural network.PLoS computational biology · 2021Article
- Genetic predisposition to tinnitus in the UK Biobank population.Scientific reports · 2021Article
- Cannabinoid Signaling in Auditory Function and Development.Frontiers in molecular neuroscience · 2021Article
- Cannabinoids, Inner Ear, Hearing, and Tinnitus: A Neuroimmunological Perspective.Frontiers in neurology · 2020Review
- Early Onset Region and Cell Specific Alterations of Doublecortin Expression in the CNS of Animals with Sound Damage Induced Hearing Loss.IBRO reports · 2019Article
- Auditory brainstem stimulation with a conformable microfabricated array elicits responses with tonotopically organized components.Hearing research · 2019Article
- Human central auditory plasticity: A review of functional near-infrared spectroscopy (fNIRS) to measure cochlear implant performance and tinnitus perception.Laryngoscope investigative otolaryngology · 2018Review
- Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity.Brain structure & function · 2018Article
- Volumes of cochlear nucleus regions in rodents.Hearing research · 2016Article
- Expression of immediate-early genes in the dorsal cochlear nucleus in salicylate-induced tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Tinnitus, the perception of a phantom sound, is a common consequence of damage to the auditory periphery. A major goal of tinnitus research is to find the loci of the neural changes that underlie the disorder. Crucial to this endeavor has been the development of an animal behavioral model of tinnitus, so that neural changes can be correlated with behavioral evidence of tinnitus. Three major lines of evidence implicate the dorsal cochlear nucleus (DCN) in tinnitus. First, elevated spontaneous activity in the DCN is correlated with peripheral damage and tinnitus. Second, there are somatosensory inputs to the DCN that can modulate spontaneous activity and might mediate the somatic-auditory interactions seen in tinnitus patients. Third, we have found a subpopulation of DCN neurons in the adult rat that express doublecortin, a plasticity-related protein. The expression of this protein may reflect a role of these neurons in the neural reorganization causing tinnitus. However, there is a problem in extending the findings in the rodent DCN to humans. Classic studies state that the structure of the primate DCN is quite different from that of rodents, with primates lacking granule cells, the recipients of somatosensory input. To address the possibility of major species differences in DCN organization, we compared Nissl-stained sections of the DCN in five different species. In contrast to earlier reports, our data suggest that the organization of the primate DCN is not dramatically different from that of the rodents, and validate the use of animal data in the study of tinnitus. This article is part of a Special Issue entitled: Tinnitus Neuroscience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.