ArticleMolecular biology of the cell2012
The inner-mitochondrial distribution of Oxa1 depends on the growth conditions and on the availability of substrates.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- PKAN pathogenesis and treatment.Molecular genetics and metabolism · 2022Review
- Protein-dependent membrane remodeling in mitochondrial morphology and clathrin-mediated endocytosis.European biophysics journal : EBJ · 2021Review
- Targeting and Insertion of Membrane Proteins in Mitochondria.Frontiers in cell and developmental biology · 2021Review
- Mitochondrial OXPHOS Biogenesis: Co-Regulation of Protein Synthesis, Import, and Assembly Pathways.International journal of molecular sciences · 2020Review
- Light Microscopy of Mitochondria at the Nanoscale.Annual review of biophysics · 2020Review
- Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Coordinated organization of mitochondrial lamellar cristae and gain of COX function during mitochondrial maturation inMolecular biology of the cell · 2020Article
- Spatial orchestration of mitochondrial translation and OXPHOS complex assembly.Nature cell biology · 2018Article
- Role of membrane contact sites in protein import into mitochondria.Protein science : a publication of the Protein Society · 2015Review
- Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The mitochondrial ADP/ATP carrier associates with the inner membrane presequence translocase in a stoichiometric manner.The Journal of biological chemistry · 2014Article
- STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Oxa1 protein is a well-conserved integral protein of the inner membrane of mitochondria. It mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane. We investigated the distribution of budding yeast Oxa1 between the two subdomains of the contiguous inner membrane--the cristae membrane (CM) and the inner boundary membrane (IBM)--under different physiological conditions. We found that under fermentable growth conditions, Oxa1 is enriched in the IBM, whereas under nonfermentable (respiratory) growth conditions, it is predominantly localized in the CM. The enrichment of Oxa1 in the CM requires mitochondrial translation; similarly, deletion of the ribosome-binding domain of Oxa1 prevents an enrichment of Oxa1 in the CM. The predominant localization in the IBM under fermentable growth conditions is prevented by inhibiting mitochondrial protein import. Furthermore, overexpression of the nuclear-encoded Oxa1 substrate Mdl1 shifts the distribution of Oxa1 toward the IBM. Apparently, the availability of nuclear- and mitochondrial-encoded substrates influences the inner-membrane distribution of Oxa1. Our findings show that the distribution of Oxa1 within the inner membrane is dynamic and adapts to different physiological needs.
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