ArticlePsychiatry research2012
Altered slow wave activity in major depressive disorder with hypersomnia: a high density EEG pilot study.
Article in Psychiatry research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Objective measures of sleep duration and continuity in major depressive disorder with comorbid hypersomnolence: a primary investigation with contiguous systematic review and meta-analysis.Journal of sleep research · 2017Pooled it
- The Space-Time Organisation of Sleep Slow Oscillations as Potential Biomarker for Hypersomnolence.Journal of sleep research · 2025Article
- Article
- Current knowledge on the pathophysiology of idiopathic hypersomnia and potential mechanisms of action for low-sodium oxybate treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Review
- Pathophysiological Models of Hypersomnolence Associated With Depression.Biological psychiatry global open science · 2025Review
- Clinical association between current depressive symptoms and odds ratio product in US sleep centers.Frontiers in sleep · 2025Article
- Sleep disturbance, but not depression severity, is associated with inflammation in children and adolescents.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Article
- Global and non-Global slow oscillations differentiate in their depth profiles.Frontiers in network physiology · 2022Article
- Non-REM sleep in major depressive disorder.NeuroImage. Clinical · 2022Article
- Aerobic fitness and the sleeping brain of adolescents-a pilot study.Sleep advances : a journal of the Sleep Research Society · 2021Article
- Sleep spindle and slow wave abnormalities in schizophrenia and other psychotic disorders: Recent findings and future directions.Schizophrenia research · 2020Article
- The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action.Frontiers in pharmacology · 2020Article
- Article
- Scalp and Source Power Topography in Sleepwalking and Sleep Terrors: A High-Density EEG Study.Sleep · 2016Article
- Article
- Hypersomnia subtypes, sleep and relapse in bipolar disorder.Psychological medicine · 2015Article
- Hypersomnia in Mood Disorders: a Rapidly Changing Landscape.Current sleep medicine reports · 2015Article
- The relationship between sleep-wake cycle and cognitive functioning in young people with affective disorders.PloS one · 2015Article
- Do prefrontal midline electrodes provide unique neurophysiologic information in Major Depressive Disorder?Journal of psychiatric research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Hypersomnolence in major depressive disorder (MDD) plays an important role in the natural history of the disorder, but the basis of hypersomnia in MDD is poorly understood. Slow wave activity (SWA) has been associated with sleep homeostasis, as well as sleep restoration and maintenance, and may be altered in MDD. Therefore, we conducted a post-hoc study that utilized high density electroencephalography (hdEEG) to test the hypothesis that MDD subjects with hypersomnia (HYS+) would have decreased SWA relative to age- and sex-matched MDD subjects without hypersomnia (HYS-) and healthy controls (n=7 for each group). After correction for multiple comparisons using statistical non-parametric mapping, HYS+ subjects demonstrated significantly reduced parieto-occipital all-night SWA relative to HYS- subjects. Our results suggest hypersomnolence may be associated with topographic reductions in SWA in MDD. Further research using an adequately powered prospective design is indicated to confirm these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.