ArticleMolecular microbiology2012
Cellular aspects of the distinct M protein and SfbI anchoring pathways in Streptococcus pyogenes.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- A modular genetic toolbox for precise gene regulation and multi-color imaging in streptococci.microLife · 2026Article
- Spatial and temporal localization of cell wall associated pili in Enterococcus faecalis.Molecular microbiology · 2023Article
- Spatial regulation of protein A in Staphylococcus aureus.Molecular microbiology · 2021Article
- Tracking the Subcellular Localization of Surface Proteins inBio-protocol · 2021Article
- The M Protein of Streptococcus pyogenes Strain AP53 Retains Cell Surface Functional Plasminogen Binding after Inactivation of the Sortase A Gene.Journal of bacteriology · 2020Article
- Surface Proteins on Gram-Positive Bacteria.Microbiology spectrum · 2019Review
- Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen.Journal of structural biology · 2019Article
- Lysibodies are IgG Fc fusions with lysin binding domains targetingProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Streptococcus pyogenes Sortase Mutants Are Highly Susceptible to Killing by Host Factors Due to Aberrant Envelope Physiology.PloS one · 2015Article
- The elongation of ovococci.Microbial drug resistance (Larchmont, N.Y.) · 2014Review
- Dual defensin strategy for targeting Enterococcus faecalis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39.Molecular microbiology · 2013Article
- The sagA/pel locus does not regulate the expression of the M protein of the M1T1 lineage of group A Streptococcus.Virulence · 2013Article
- SecA localization and SecA-dependent secretion occurs at new division septa in group B Streptococcus.PloS one · 2013Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Wall-anchored surface proteins are critical for the in vivo survival of Streptococcus pyogenes. Cues in the signal sequence direct the membrane translocation of surface proteins: M protein to the septum, and SfbI to the poles. Both proteins are subsequently anchored to the wall by the membrane bound enzyme sortase A. However, the cellular features of these pathways are not fully understood. Here we show that M protein and SfbI are anchored simultaneously throughout the cell cycle. M protein is rapidly anchored at the septum, and in part of the cell cycle, is anchored simultaneously at the mother and daughter septa. Conversely, SfbI accumulates gradually on peripheral peptidoglycan, resulting in a polar distribution. Sortase is not required for translocation of M protein or SfbI at their respective locations. Methicillin-induced unbalanced peptidoglycan synthesis diminishes surface M protein but not SfbI. Furthermore, overexpression of the division regulator DivIVA also diminishes surface M protein but increases SfbI. These results demonstrate a close connection between the regulation of cell division and protein anchoring. Better understanding of the spatial regulation of surface anchoring may lead to the identification of novel targets for the development of anti-infective agents, given the importance of surface molecules for pathogenesis.
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