Evidence map›Paper›PMID 22512348›Full record

Trial reportHeadache2012

tDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine.

Alexandre F Dasilva, Mariana E Mendonca, Soroush Zaghi, Mariana Lopes, Marcos Fabio Dossantos, Egilius L Spierings, Zahid Bajwa, Abhishek Datta, Marom Bikson, Felipe Fregni

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Headache, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 116 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 7 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04336267 nacompletednot on this mapstarted 2015, after this paper: background citation

Anodal Transcranial Direct Current Stimulation in Chronic Migraine With and Medication Overuse Headache: a Pilot Randomized Sham-controlled Trial

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2015 to 2018Enrolled20ConditionsChronic Migraine, Medication Overuse HeadacheArmsTranscranial direct current stimulation (tDCS) group, Sham group
NCT06640634 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Anodal Transcranial Direct Current Stimulation on Postdural Puncture Headache: Results of Two Randomized Sham - Controlled Trials

TypeinterventionalSponsorNeuromed IRCCSRan2022 to 2024Enrolled97ConditionsPostdural Puncture Headache, Lumbar PunctureArmsactive in therapeutic tDCS (Th-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS), sham in therapeutic tDCS (Th-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS), active in preventive tDCS (Pr-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS), sham in preventive tDCS (Pr-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS)
3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 7 syntheses or guidelines pooled it, 304 citations in OpenAlex.

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  11. High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
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  12. Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.Neuromodulation : journal of the International Neuromodulation Society · 2023
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Alexandre F DasilvaHeadache & Orofacial Pain Effort, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Mariana E Mendonca
Soroush Zaghi
Mariana Lopes
Marcos Fabio Dossantos
Egilius L Spierings
Zahid Bajwa
Abhishek Datta
Marom Bikson
Felipe Fregni
Berenson Allen Center for Noninvasive Brain Stimulation · USMassachusetts General Hospital · USUniversity of Michigan–Ann Arbor · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USSpaulding Rehabilitation Hospital · US

Funding

MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)UL1RR024986 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2007 to 2011
$51.2M
University of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1M
Structural and Molecular Neuroplasticity in Chronic Trigeminal PainK23NS062946 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE · 2009 to 2013
$779k
NCRR NIH HHS UL1 RR024986NIGMS NIH HHS R25 GM086262NINDS NIH HHS K23 NS062946
6 · The paper itself

Abstract

objectiveWe investigated in a sham-controlled trial the analgesic effects of a 4-week treatment of transcranial direct current stimulation (tDCS) over the primary motor cortex in chronic migraine. In addition, using a high-resolution tDCS computational model, we analyzed the current flow (electric field) through brain regions associated with pain perception and modulation.

methodsThirteen patients with chronic migraine were randomized to receive 10 sessions of active or sham tDCS for 20 minutes with 2 mA over 4 weeks. Data were collected during baseline, treatment and follow-up. For the tDCS computational analysis, we adapted a high-resolution individualized model incorporating accurate segmentation of cortical and subcortical structures of interest.

resultsThere was a significant interaction term (time vs group) for the main outcome (pain intensity) and for the length of migraine episodes (ANOVA, P < .05 for both analyses). Post-hoc analysis showed a significant improvement in the follow-up period for the active tDCS group only. Our computational modeling studies predicted electric current flow in multiple cortical and subcortical regions associated with migraine pathophysiology. Significant electric fields were generated, not only in targeted cortical regions but also in the insula, cingulate cortex, thalamus, and brainstem regions.

conclusionsOur findings give preliminary evidence that patients with chronic migraine have a positive, but delayed, response to anodal tDCS of the primary motor cortex. These effects may be related to electrical currents induced in pain-related cortical and subcortical regions.

Indexed as

AdolescentAdultAnalgesiaElectric Stimulation TherapyFemaleHumansMaleMiddle AgedMigraine DisordersMotor CortexNerve NetPainPain ManagementPain MeasurementPain PerceptionSingle-Blind Method

Identifiers

PMID22512348
PMCPMC4166674
OpenAlexW2098114243

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.