ArticleLangmuir : the ACS journal of surfaces and colloids2012
DNA electrochemistry with tethered methylene blue.
Article in Langmuir : the ACS journal of surfaces and colloids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Evaluating Hybridization Chain Reaction to Improve miRNA Measurements at Portable Electroanalytical Strip: miRNA-21 as a Case of Study.ACS omega · 2026Article
- Computational Framework for High Copy-Number Probe Selection and Cross-Binding Reduction.Analytical science advances · 2025Article
- Methylene blue as a new signal tracer for nucleic acid-based lateral flow assay.Scientific reports · 2025Article
- Future perspectives of GMO detection in agriculture: strategies for electrochemical nucleic acid detection.Mikrochimica acta · 2025Review
- 3D printed electrode-microwell system: a novel electrochemical platform for miRNA detection.Mikrochimica acta · 2025Article
- A toolbox for enzymatic modification of nucleic acids with photosensitizers for photodynamic therapy.RSC chemical biology · 2024Article
- The Influence of 5',8-Cyclo-2'-Deoxyguanosine on ds-DNA Charge Transfer Depends on Its Diastereomeric Form: A Theoretical Study.Antioxidants (Basel, Switzerland) · 2023Article
- A Review of Detection Methods for Vancomycin-ResistantBiosensors · 2023Review
- Controlling Dynamic DNA Reactions at the Surface of Single-Walled Carbon Nanotube Electrodes to Design Hybridization Platforms with a Specific Amperometric Readout.Analytical chemistry · 2022Article
- A Quantification of Target Protein Biomarkers in Complex Media by Faradaic Shotgun Tagging.Analytical chemistry · 2022Article
- DNA Electrochemistry: Charge-Transport Pathways through DNA Films on Gold.Journal of the American Chemical Society · 2021Article
- Conformational Changes of Immobilized Polythymine due to External Stressors Studied with Temperature-Controlled Electrochemical Microdevices.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Increasing the Sensitivity of Electrochemical DNA Detection by a Micropillar-Structured Biosensing Surface.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Tuning of Oxidation Potential of Ferrocene for Ratiometric Redox Labeling and Coding of Nucleotides and DNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- High-Precision Electrochemical Measurements of the Guanine-, Mismatch-, and Length-Dependence of Electron Transfer from Electrode-Bound DNA Are Consistent with a Contact-Mediated Mechanism.Journal of the American Chemical Society · 2019Article
- Gate-controlled conductance switching in DNA.Nature communications · 2017Article
- Electrical Probes of DNA-Binding Proteins.Methods in enzymology · 2017Article
- Redox Signaling through DNA.Israel journal of chemistry · 2016Article
- Controllable Molecule Transport and Release by a Restorable Surface-tethered DNA nanodevice.Scientific reports · 2016Article
- Reagentless, Structure-Switching, Electrochemical Aptamer-Based Sensors.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Methylene blue (MB'), covalently attached to DNA through a flexible C(12) alkyl linker, provides a sensitive redox reporter in DNA electrochemistry measurements. Tethered, intercalated MB' is reduced through DNA-mediated charge transport; the incorporation of a single base mismatch at position 3, 10, or 14 of a 17-mer causes an attenuation of the signal to 62 ± 3% of the well-matched DNA, irrespective of position in the duplex. The redox signal intensity for MB'-DNA is found to be least 3-fold larger than that of Nile blue (NB)-DNA, indicating that MB' is even more strongly coupled to the π-stack. The signal attenuation due to an intervening mismatch does, however, depend on DNA film density and the backfilling agent used to passivate the surface. These results highlight two mechanisms for reduction of MB' on the DNA-modified electrode: reduction mediated by the DNA base pair stack and direct surface reduction of MB' at the electrode. These two mechanisms are distinguished by their rates of electron transfer that differ by 20-fold. The extent of direct reduction at the surface can be controlled by assembly and buffer conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.