ArticlePloS one2012
Supernumerary formation of olfactory glomeruli induced by chronic odorant exposure: a constructivist expression of neural plasticity.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Lack of Structural Change in Olfactory Circuitry Following Fecal Microbiome Transplant From Donors Subjected to Diet-induced Obesity.Journal of neurochemistry · 2026Article
- How early olfactory experiences influence brain development in mice.Frontiers in neural circuits · 2025Review
- The influence of olfactory experience on the birthrates of olfactory sensory neurons with specific odorant receptor identities.Genesis (New York, N.Y. : 2000) · 2024Review
- Activity-dependent formation of the topographic map and the critical period in the development of mammalian olfactory system.Genesis (New York, N.Y. : 2000) · 2024Review
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- Can social behaviour drive accessory olfactory bulb asymmetries? Sister species of caviomorph rodents as a case in point.Journal of anatomy · 2020Article
- Article
- Differential timing of neurogenesis underlies dorsal-ventral topographic projection of olfactory sensory neurons.Neural development · 2017Article
- Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice.Chemical senses · 2016Article
- Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory.Development (Cambridge, England) · 2015Article
- Odorant receptors signaling instructs the development and plasticity of the glomerular map.Neural plasticity · 2015Review
- A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli.Open biology · 2013Article
- Changes in the neural representation of odorants after olfactory deprivation in the adult mouse olfactory bulb.Chemical senses · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is accepted that sensory experience instructs the remodelling of neuronal circuits during postnatal development, after their specification has occurred. The story is less clear with regard to the role of experience during the initial formation of neuronal circuits, whether prenatal or postnatal, since this process is now supposed to be primarily influenced by genetic determinants and spontaneous neuronal firing. Here we evaluated this last issue by examining the effect that postnatal chronic exposure to cognate odorants has on the formation of I7 and M72 glomeruli, iterated olfactory circuits that are formed before and after birth, respectively. We took advantage of double knock-in mice whose I7 and M72 primary afferents express green fluorescent protein and β-galactosidase, correspondingly. Our results revealed that postnatal odorant chronic exposure led to the formation of permanent supernumerary I7 and M72 glomeruli in a dose and time dependent manner. Glomeruli in exposed mice were formed within the same regions of olfactory bulb and occupy small space volumes compared to the corresponding single circuits in non-exposed mice. We suggest that local reorganization of the primary afferents could participate in the process of formation of supernumerary glomeruli. Overall, our results support that sensory experience indeed instructs the permanent formation of specific glomeruli in the mouse olfactory bulb by means of constructivist processes.
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