ArticlePLoS genetics2012
Mu insertions are repaired by the double-strand break repair pathway of Escherichia coli.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- De novo-engineered guide RNA-directed transposition with TnpB-family proteins.Molecular cell · 2026Article
- Identification of proteins influencing CRISPR-associated transposases for enhanced genome editing.Science advances · 2026Article
- Elucidating the Architectural dynamics of MuB filaments in bacteriophage Mu DNA transposition.Nature communications · 2024Article
- Phage Mu Gam protein promotes NHEJ in concert withProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Single-strand DNA processing: phylogenomics and sequence diversity of a superfamily of potential prokaryotic HuH endonucleases.BMC genomics · 2018Article
- Replication Restart in Bacteria.Journal of bacteriology · 2017Review
- DNA Transposition at Work.Chemical reviews · 2016Review
- Article
- Repair of transposable phage Mu DNA insertions begins only when the E. coli replisome collides with the transpososome.Molecular microbiology · 2015Article
- Mechanisms of DNA Transposition.Microbiology spectrum · 2015Review
- Transposable Phage Mu.Microbiology spectrum · 2014Review
- Mu transpososome and RecBCD nuclease collaborate in the repair of simple Mu insertions.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Chromosomal replication dynamics and interaction with the β sliding clamp determine orientation of bacterial transposable elements.Genome biology and evolution · 2014Article
- Structural insight into the DNA-binding mode of the primosomal proteins PriA, PriB, and DnaT.BioMed research international · 2014Article
- Genetic and biochemical assays reveal a key role for replication restart proteins in group II intron retrohoming.PLoS genetics · 2013Article
- The Mu story: how a maverick phage moved the field forward.Mobile DNA · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mu is both a transposable element and a temperate bacteriophage. During lytic growth, it amplifies its genome by replicative transposition. During infection, it integrates into the Escherichia coli chromosome through a mechanism not requiring extensive DNA replication. In the latter pathway, the transposition intermediate is repaired by transposase-mediated resecting of the 5' flaps attached to the ends of the incoming Mu genome, followed by filling the remaining 5 bp gaps at each end of the Mu insertion. It is widely assumed that the gaps are repaired by a gap-filling host polymerase. Using the E. coli Keio Collection to screen for mutants defective in recovery of stable Mu insertions, we show in this study that the gaps are repaired by the machinery responsible for the repair of double-strand breaks in E. coli-the replication restart proteins PriA-DnaT and homologous recombination proteins RecABC. We discuss alternate models for recombinational repair of the Mu gaps.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.