ArticlePLoS pathogens2012
Necrotrophism is a quorum-sensing-regulated lifestyle in Bacillus thuringiensis.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 105 citations in OpenAlex.
- A taste of one's own medicine:Frontiers in immunology · 2025Article
- Role of bacterial quorum sensing in plant growth promotion.World journal of microbiology & biotechnology · 2024Review
- Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness ofbioRxiv : the preprint server for biology · 2024Article
- Extracellular proteolysis of tandemly duplicated pheromone propeptides affords additional complexity to bacterial quorum sensing.PLoS biology · 2024Article
- Apple cider vinegar exhibits promising antibiofilm activity against multidrug-resistantOpen veterinary journal · 2024Article
- Group Selection as a Basis for Screening Mutagenized Libraries of Public Goods (Bacillus thuringiensis Cry Toxins).Applied and environmental microbiology · 2023Article
- Targeting Peptide-Based Quorum Sensing Systems for the Treatment of Gram-Positive Bacterial Infections.Peptide science (Hoboken, N.J.) · 2023Article
- Classification and Multifaceted Potential of Secondary Metabolites Produced byMolecules (Basel, Switzerland) · 2023Review
- Article
- Tandem Mass Tag-Based Quantitative Proteomics and Virulence Phenotype of Hemolymph-Treated Bacillus thuringiensis kurstaki Cells Reveal New Insights on Bacterial Pathogenesis in Insects.Microbiology spectrum · 2021Article
- Immune Inhibitor A Metalloproteases Contribute to Virulence inInfection and immunity · 2021Article
- TheMicrobiology (Reading, England) · 2021Article
- Rap-Phr Systems from Plasmids pAW63 and pHT8-1 Act Together To Regulate Sporulation in the Bacillus thuringiensis Serovar kurstaki HD73 Strain.Applied and environmental microbiology · 2020Article
- Multiple and Overlapping Functions of Quorum Sensing Proteins for Cell Specialization inJournal of bacteriology · 2020Review
- Expression ofMicroorganisms · 2020Article
- AToxins · 2020Article
- Rap Protein Paralogs of Bacillus thuringiensis: a Multifunctional and Redundant Regulatory Repertoire for the Control of Collective Functions.Journal of bacteriology · 2020Article
- MogR Is a Ubiquitous Transcriptional Repressor Affecting Motility, Biofilm Formation and Virulence inFrontiers in microbiology · 2020Article
- Integrated Transcriptomic and Proteomic Analyses Reveal the Role of NprR inFrontiers in microbiology · 2020Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How pathogenic bacteria infect and kill their host is currently widely investigated. In comparison, the fate of pathogens after the death of their host receives less attention. We studied Bacillus thuringiensis (Bt) infection of an insect host, and show that NprR, a quorum sensor, is active after death of the insect and allows Bt to survive in the cadavers as vegetative cells. Transcriptomic analysis revealed that NprR regulates at least 41 genes, including many encoding degradative enzymes or proteins involved in the synthesis of a nonribosomal peptide named kurstakin. These degradative enzymes are essential in vitro to degrade several substrates and are specifically expressed after host death suggesting that Bt has an active necrotrophic lifestyle in the cadaver. We show that kurstakin is essential for Bt survival during necrotrophic development. It is required for swarming mobility and biofilm formation, presumably through a pore forming activity. A nprR deficient mutant does not develop necrotrophically and does not sporulate efficiently in the cadaver. We report that necrotrophism is a highly regulated mechanism essential for the Bt infectious cycle, contributing to spore spreading.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.