Evidence map›Paper›PMID 22511822›Full record

ArticleBulletin of the World Health Organization2012

Likely effectiveness of pharmaceutical and non-pharmaceutical interventions for mitigating influenza virus transmission in Mongolia.

K J Bolton, J M McCaw, R Moss, R S Morris, S Wang, A Burma, B Darma, D Narangerel, P Nymadawa, J McVernon

Open access · diamondAbstract read
In one paragraph

Article in Bulletin of the World Health Organization, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pharmaceuticals (Basel, Switzerland) · 2026
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  8. Reflecting on prediction strategies for epidemics: Preparedness and public health response.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021
    Review
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  16. Influenza at the beginning of the 21st century.Bulletin of the World Health Organization · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

K J BoltonMelbourne School of Population Health, University of Melbourne, Carlton, Victoria 3010, Australia. kbolton@unimelb.edu.au
J M McCaw
R Moss
R S Morris
S Wang
A Burma
B Darma
D Narangerel
P Nymadawa
J McVernon
University of Melbourne · AUMelbourne Health · AU

Funding

DEVELOPING SUSTAINABLE INFLUENZA SURVEILLANCE NETWORKS AND RESPONSE TO AVIAN AND U51IP000331 · IP · MINISTRY OF HEALTH MONGOLIA · PI NYMADAWA, PAGBAJABYN · 2009 to 2013
$2.0M
NCIRD CDC HHS IU51IP000331NCIRD CDC HHS U51 IP000331PHS HHS U50/CCU024411
6 · The paper itself

Abstract

objectiveTo assess the likely benefit of the interventions under consideration for use in Mongolia during future influenza pandemics.

methodsA stochastic, compartmental patch model of susceptibility, exposure, infection and recovery was constructed to capture the key effects of several interventions--travel restrictions, school closure, generalized social distancing, quarantining of close contacts, treatment of cases with antivirals and prophylaxis of contacts--on the dynamics of influenza epidemics. The likely benefit and optimal timing and duration of each of these interventions were assessed using Latin-hypercube sampling techniques, averaging across many possible transmission and social mixing parameters.

findingsTimely interventions could substantially alter the time-course and reduce the severity of pandemic influenza in Mongolia. In a moderate pandemic scenario, early social distancing measures decreased the mean attack rate from around 10% to 7-8%. Similarly, in a severe pandemic scenario such measures cut the mean attack rate from approximately 23% to 21%. In both moderate and severe pandemic scenarios, a suite of non-pharmaceutical interventions proved as effective as the targeted use of antivirals. Targeted antiviral campaigns generally appeared more effective in severe pandemic scenarios than in moderate pandemic scenarios.

conclusionA mathematical model of pandemic influenza transmission in Mongolia indicated that, to be successful, interventions to prevent transmission must be triggered when the first cases are detected in border regions. If social distancing measures are introduced at this stage and implemented over several weeks, they may have a notable mitigating impact. In low-income regions such as Mongolia, social distancing may be more effective than the large-scale use of antivirals.

Indexed as

Antiviral AgentsChemopreventionHumansInfluenza, HumanModels, TheoreticalMongoliaOrthomyxoviridaePandemicsPatient IsolationSentinel SurveillanceSocial IsolationStochastic ProcessesTravelAntiviral Agents

Identifiers

PMID22511822
PMCPMC3324865
OpenAlexW2110592222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.