ArticleArthritis care & research2012
Umbilical cord blood levels of maternal antibodies reactive with p200 and full-length Ro 52 in the assessment of risk for cardiac manifestations of neonatal lupus.
Article in Arthritis care & research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00074373 (The Research Registry for Neonatal Lupus), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Research Registry for Neonatal Lupus
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation.Circulation. Arrhythmia and electrophysiology · 2020Trial
- Gut microbiota dysbiosis and host metabolite-immune crosstalk drives the pathogenesis of neonatal lupus erythematosus: a multi-omics analysis.BMC medicine · 2026Article
- Variation in prenatal surveillance and management of anti-SSA/Ro autoantibody positive pregnancies.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2024Article
- Molecular Mechanisms of Fetal and Neonatal Lupus: A Narrative Review of an Autoimmune Disease Transferal across the Placenta.International journal of molecular sciences · 2024Review
- Reducing the burden of surveillance in pregnant women with no history of fetal atrioventricular block using the negative predictive value of anti-Ro/SSA antibody titers.American journal of obstetrics and gynecology · 2022Article
- Cardiac manifestations in a Chinese cohort of fetuses from mothers with anti-Ro and anti-La antibodies.Frontiers in pediatrics · 2022Article
- Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus.The Journal of experimental medicine · 2021Article
- The Autoantigen Repertoire and the Microbial RNP World.Trends in molecular medicine · 2021Review
- Salivary dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus.Journal of autoimmunity · 2020Article
- Autoimmune Congenital Heart Block: A Review of Biomarkers and Management of Pregnancy.Frontiers in pediatrics · 2020Review
- Autoimmune Calcium Channelopathies and Cardiac Electrical Abnormalities.Frontiers in cardiovascular medicine · 2019Review
- Progress in the pathogenesis and treatment of cardiac manifestations of neonatal lupus.Current opinion in rheumatology · 2017Review
- Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.Journal of autoimmunity · 2017Article
- Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model.Clinical and experimental immunology · 2016Article
- Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity.Journal of autoimmunity · 2016Article
- In search of an antibody specificity highly predictive of congenital heart block.Lupus science & medicine · 2016Article
- Maternal autoantibody profiles at risk for autoimmune congenital heart block: a prospective study in high-risk patients.Lupus science & medicine · 2016Article
- The clinical spectrum of autoimmune congenital heart block.Nature reviews. Rheumatology · 2015Review
- Gut dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus.Gut microbesArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveMaternal anti-Ro autoantibodies are associated with cardiac manifestations of neonatal lupus (cardiac NL), yet only 2% of women with this reactivity have an affected child. Identification of a more specific marker would channel intense monitoring to fetuses at greater risk. This study aimed to determine whether autoantibodies against Ro 52 amino acids 200-239 (p200) confer added risk over autoantibodies to full-length Ro 52, Ro 60, or La.
methodsAnti-Ro-exposed pregnancies resulting in cardiac NL or no cardiac manifestations were identified from the Research Registry for Neonatal Lupus and the PR Interval and Dexamethasone Evaluation study. Umbilical cord (n = 123) and maternal (n = 115) samples were evaluated by enzyme-linked immunosorbent assay.
resultsThe frequencies of p200, Ro 52, Ro 60, and La autoantibodies were not significantly different between affected and unaffected children. However, neonatal anti-Ro 52 and Ro 60 titers were highest in cardiac NL and their unaffected siblings compared to unaffected neonates without a cardiac NL sibling. Although both maternal anti-Ro 52 and p200 autoantibodies were less than 50% specific for cardiac NL, anti-p200 was the least likely of the Ro autoantibodies to be false-positive in mothers who have never had an affected child. Titers of anti-Ro 52 and p200 did not differ during a cardiac NL or unaffected pregnancy from the same mother.
conclusionMaternal reactivity to p200 does not confer an added risk to fetal conduction defects over full-length Ro 52 or Ro 60 autoantibodies. Mothers who may never be at risk for having an affected child have lower anti-Ro 60 titers and may require less stringent echocardiographic monitoring compared to women with high-titer autoantibodies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.