ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2013
Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 490 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Frailty in Patient Undergoing Percutaneous Left Atrial Appendage Closure The Frail-LAAC Study
Prospective Cohort for the Study of Phenotypic Clusters, Progression Paths and Outcomes of Frailty and Dependence: The Spanish CohorFES
Clinical Efficacy of a Multicomponent Exercise and Comprehensive Geriatric Assessment Program (FRAIL+AP) in Frail Older Adults Within Primary Care: A Randomized Controlled Trial
Who cites it
490 citing papers in PubMed, 11 syntheses or guidelines pooled it, 1,178 citations in OpenAlex.
- Effect of Prehabilitation on the 6-Minute Walk Test and Length of Hospital Stay in Frail Older People: A Meta-Analysis of Randomized Controlled Trials.International journal of environmental research and public health · 2025Pooled it
- The prognostic role of Geriatric 8 in patients with cancer: a meta-analysis and systematic review.The oncologist · 2025Pooled it
- Frailty and pituitary surgery: a systematic review.Pituitary · 2025Pooled it
- Frailty Screening Using the Risk Analysis Index: A User Guide.Joint Commission journal on quality and patient safety · 2025Pooled it
- From guidelines to clinical practice in care for ischaemic stroke patients: A systematic review and expert opinion.European journal of neurology · 2024Pooled it
- Health-related quality of life measures provide information on the contributors, components, and consequences of frailty in HIV: a systematic mapping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Gut microbiome and frailty: insight from genetic correlation and mendelian randomization.Gut microbes · 2023Pooled it
- Frailty score and outcomes of patients undergoing vascular surgery and amputation: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Pooled it
- High-intensity interval training among middle-aged and older adults for body composition and muscle strength: A systematic review.Frontiers in public health · 2022Pooled it
- Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis.Ageing research reviews · 2021Pooled it
- Pooled it
- Telerehabilitation for frail cirrhotic patients awaiting liver transplant: A safe, effective strategy to improve outcomes.World journal of hepatology · 2025Trial
- Trial
- Functional mobility and physical fitness are improved through a multicomponent training program in institutionalized older adults.GeroScience · 2024Trial
- Serum metabolomic signatures associated with frailty-related phenotypes in a cohort of older people.GeroScience · 2026Article
- Association of frailty indices with post-operative outcomes in shoulder surgery: a systematic review.JSES reviews, reports, and techniques · 2026Review
- Changes in physical performance and frailty-associated risk associated with participation in a community exercise programme: Findings from the ExWell cohort.The Journal of frailty & aging · 2026Article
- Frailty Assessment and Its Impact in Hospital Outcomes After Cardiac Surgery - A Prospective Observational Study.Brazilian journal of cardiovascular surgery · 2026Observational
- Factors associated with sustained robustness in older adults: an 8-year multinational longitudinal study using SHARE data.BMC geriatrics · 2026Observational
- Association between clinical frailty and multidrug-resistant positive cultures in hospitalized older adults.Internal and emergency medicine · 2026Article
430 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 20 institutions in 9 countries.
Funding
Abstract
backgroundThere is no consensus regarding the definition of frailty for clinical uses.
methodsA modified Delphi process was used to attempt to achieve consensus definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire was developed and sent to experts in the area of frailty. Responses and comments were analyzed using a pre-established strategy. Statements with an agreement more than or equal to 80% were accepted.
resultsOverall, 44% of the statements regarding the concept of frailty and 18% of the statements regarding diagnostic criteria were accepted. There was consensus on the value of screening for frailty and about the identification of six domains of frailty for inclusion in a clinical definition, but no agreement was reached concerning a specific set of clinical/laboratory biomarkers useful for diagnosis.
conclusionsThere is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions. However, additional research is needed before an operative definition of frailty can be established.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.