Evidence map›Paper›PMID 22511139›Full record

ReviewCritical care medicine2012

Genetics and genomics in pediatric septic shock.

Hector R Wong

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
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  20. Precision medicine in pediatric sepsis.Current opinion in pediatrics · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Hector R WongDivision of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. hector.wong@cchmc.org
Cincinnati Children's Hospital Medical Center · US

Funding

Genomic analysis of pediatric SIRS and septic shockR01GM064619 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WONG, HECTOR R. · 2003 to 2009
$3.0M
Stratification of pediatric septic shockR01GM099773 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WONG, HECTOR R. · 2012 to 2015
$1.5M
MMP-8 as a novel therapeutic target in sepsisR01GM096994 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WONG, HECTOR R. · 2011 to 2014
$1.2M
THE PEDIATRIC SEPSIS BIOMARKER RISK MODELRC1HL100474 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WONG, HECTOR R. · 2009 to 2010
$1000k
NHLBI NIH HHS RC1 HL100474NHLBI NIH HHS RC1HL100474NIGMS NIH HHS R01 GM064619NIGMS NIH HHS R01-GM064619NIGMS NIH HHS R01 GM096994NIGMS NIH HHS R01GM096994NIGMS NIH HHS R01 GM099773
6 · The paper itself

Abstract

objectivesPediatric septic shock continues to be an important public health problem. Several investigative groups have applied genetic and genomic approaches as a means of identifying novel pathways and therapeutic targets, discovery of sepsis-related biomarkers, and identification of septic shock subclasses. This review will highlight studies in pediatric sepsis with a focus on gene association studies and genome-wide expression profiling. DATA SOURCES: A summary of published literature involving gene association and expression profiling studies specifically involving pediatric sepsis and septic shock. SUMMARY: Several polymorphisms of genes broadly involved in inflammation, immunity, and coagulation have been linked with susceptibility to sepsis, or outcome of sepsis in children. Many of these studies involve meningococcemia, and the strongest association involves a functional polymorphism of the plasminogen activator inhibitor-1 promoter region and meningococcal sepsis. Expression profiling studies in pediatric septic shock have identified zinc supplementation and inhibition of matrix metalloproteinase-8 activity as potential, novel therapeutic approaches in sepsis. Studies focused on discovery of sepsis-related biomarkers have identified interleukin-8 as a robust outcome biomarker in pediatric septic shock. Additional studies have demonstrated the feasibility and clinical relevance of gene expression-based subclassification of pediatric septic shock.

conclusionsPediatric sepsis and septic shock are increasingly being studied by genetic and genomic approaches and the accumulating data hold the promise of enhancing our future approach to this ongoing clinical problem.

Indexed as

ChildEpigenomicsGene Expression ProfilingGenetic MarkersGenome-Wide Association StudyHumansPlasminogen Activator Inhibitor 1Polymorphism, Single NucleotideShock, SepticToll-Like ReceptorsTumor Necrosis Factor-alphaGenetic MarkersPlasminogen Activator Inhibitor 1Toll-Like ReceptorsTumor Necrosis Factor-alpha

Identifiers

PMID22511139
PMCPMC3329642
OpenAlexW2120237086

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.