Evidence map›Paper›PMID 22510896›Full record

ArticleAnnals of plastic surgery2012

Adipose-derived stromal cells accelerate wound healing in an organotypic raft culture model.

Sherry S Collawn, N Sanjib Banerjee, Jorge de la Torre, Luis Vasconez, Louise T Chow

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of plastic surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. [Research progress of adipose-derived stem cells in skin wound healing].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2017
    Review
  10. Review
  11. Article
  12. The Use of Stem Cells in Burn Wound Healing: A Review.BioMed research international · 2015
    Review
  13. Review
  14. Article
  15. [Stem cell derived therapy for cutaneous radiation exposure].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2013
    Review
  16. Article
  17. Review
  18. New hope for wound healing after bowel resection.Journal of the Korean Society of Coloproctology · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sherry S CollawnDivision of Plastic Surgery, University of Alabama, Birmingham, AL, USA. scollawn@uabmc.edu
N Sanjib Banerjee
Jorge de la Torre
Luis Vasconez
Louise T Chow

Funding

MECHANISMS OF HUMAN PAPILLOMAVIRUS DNA REPLICATIONR01CA083679 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHOW, LOUISE T · 1999 to 2015
$5.1M
NCI NIH HHS CA83679NCI NIH HHS R01 CA083679
6 · The paper itself

Abstract

Adipose tissue is a known reservoir of multipotent mesenchymal stem cells, which can be manipulated in culture to produce cells with different phenotypes. The goal of this study was to determine whether the addition of these multipotential cells to organotypic, human skin equivalent cultures would accelerate wound healing after laser injury. For our initial studies, we were able to obtain 3-dimensional raft cultures from adult skin explanted directly onto the dermal equivalent containing human fibroblasts with or without adipose-derived stromal cells (ADSCs). Two days after laser injury, the raft cultures of skin explants that contained ADSCs had a completely healed multilayered epidermis, whereas the control raft culture without the adipose-derived cells still had areas of injury. With this encouraging outcome, these experiments were then repeated in a raft culture system initiated from dissociated primary adult human keratinocytes on the humanized dermal equivalent. Again, the cultures containing ADSCs healed faster than the control cultures. In conclusion, these data provide support to our hypothesis that ADSCs are an excellent and readily available source of factors necessary for accelerated wound healing and tissue regeneration.

Indexed as

Skin Physiological PhenomenaWound HealingAdipocytesAdipose TissueAdultAnimalsBurnsCells, CulturedFibroblastsHumansKeratinocytesLasers, GasRadiation InjuriesRatsSkinStromal Cells

Identifiers

PMID22510896
PMCPMC3477580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.