Evidence map›Paper›PMID 22510569›Full record

ReviewCell cycle (Georgetown, Tex.)2012

Developmental decisions: balancing genetics and the environment by C. elegans.

David V Tobin, Richard Mako Saito

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David V TobinDepartment of Genetics, Dartmouth Medical School, Hanover, NH, USA.
Richard Mako Saito
Dartmouth College · US

Funding

Genetic and biochemical analysis of cdc-14R01GM077031 · NIGMS · DARTMOUTH COLLEGE · PI SAITO, R. MAKO · 2007 to 2011
$1.5M
NIGMS NIH HHS GM077031NIGMS NIH HHS R01 GM077031
6 · The paper itself

Abstract

The small nematode C. elegans is characterized by developing through a highly coordinated, reproducible cell lineage that serves as the basis of many studies focusing on the development of multi-lineage organisms. Indeed, the reproducible cell lineage enables discovery of developmental defects that occur in even a single cell. Only recently has attention been focused on how these animals modify their genetically programmed cell lineages to adapt to altered environments. Here, we summarize the current understanding of how C. elegans responds to food deprivation by adapting their developmental program in order to conserve energy. In particular, we highlight the AMPK-mediated and insulin-like growth factor signaling pathways that are the principal regulators of induced cell cycle quiescence.

Indexed as

EnvironmentSignal TransductionAdaptation, PhysiologicalAMP-Activated Protein KinasesAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell Cycle CheckpointsCell DivisionCell LineageFood DeprivationGerm CellsInsulin-Like Growth Factor IReceptor Cross-TalkAMP-Activated Protein KinasesCaenorhabditis elegans ProteinsInsulin-Like Growth Factor I

Identifiers

PMID22510569
PMCPMC3372391
OpenAlexW2051878262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.