ArticleDiagnostic pathology2012
Clinicopathological significance of SOX4 expression in primary gallbladder carcinoma.
Article in Diagnostic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- SOX4 is a potential prognostic factor in human cancers: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Pooled it
- DRMref: comprehensive reference map of drug resistance mechanisms in human cancer.Nucleic acids research · 2024Article
- Knockdown of LINC01694 inhibits growth of gallbladder cancer cells via miR-340-5p/Sox4.Bioscience reports · 2020Observational
- SOX4 promotes the growth and metastasis of breast cancer.Cancer cell international · 2020Article
- Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish.Blood cancer journal · 2017Article
- SOX4 promotes melanoma cell migration and invasion though the activation of the NF-κB signaling pathway.International journal of molecular medicine · 2017Article
- Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.World journal of gastroenterology · 2017Review
- Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.Scientific reports · 2016Article
- SOX4 Promotes Progression in OLP-Associated Squamous Cell Carcinoma.Journal of Cancer · 2016Article
- SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2.Cell death & disease · 2015Article
- miR-132 inhibits lung cancer cell migration and invasion by targeting SOX4.Journal of thoracic disease · 2015Article
- SOX4 overexpression is a novel biomarker of malignant status and poor prognosis in breast cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Increased expression of SOX4 is a biomarker for malignant status and poor prognosis in patients with non-small cell lung cancer.Molecular and cellular biochemistry · 2015Article
- Upregulated Expression of SOX4 Is Associated with Tumor Growth and Metastasis in Nasopharyngeal Carcinoma.Disease markers · 2015Article
- SOX4 expression is closely associated with differentiation and lymph node metastasis in oral squamous cell carcinoma.Medical molecular morphology · 2014Article
- Clinicopathological correlation and prognostic significance of sonic hedgehog protein overexpression in human gastric cancer.International journal of clinical and experimental pathology · 2014Article
- The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2013Article
- Pleiotropic function of SRY-related HMG box transcription factor 4 in regulation of tumorigenesis.Cellular and molecular life sciences : CMLS · 2013Review
- The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?Oncogene · 2013Review
- Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimSOX4, as a member of the SRY-related HMG-box (SOX) transcription factor family, has been demonstrated to be involved in tumorigenesis of many human malignancies; however, its role in primary gallbladder carcinoma (PGC) is still largely unknown. The aim of this study was to investigate SOX4 expression in PGC and its prognostic significance.
methodsFrom 1997 to 2006, 136 patients underwent resection for PGC. The median follow-up was 12.8 months. Immunostainings for SOX4 were performed on these archival tissues. The correlation of SOX4 expression with clinicopathological features including survival was analyzed.
resultsSOX4 was expressed in 75.0% (102/136) of PGC but not in the normal epithelium of the gallbladder. In addition, the over-expression of SOX4 was significantly associated with low histologic grade (P = 0.02), low pathologic T stage (P = 0.02), and early clinical stage (P = 0.03). The levels of SOX4 immunostainings in PGC tissues with positive nodal metastasis were also significantly lower than those without (P = 0.01). Moreover, Kaplan-Meier curves showed that SOX4 over-expression was significantly related to better overall (P = 0.008) and disease-free survival (P = 0.01). Furthermore, multivariate analyses showed that SOX4 expression was an independent risk factor for both overall (P = 0.03, hazard ratio, 3.682) and disease-free survival (P = 0.04, hazard ratio, 2.215).
conclusionOur data indicate for the first time that the over-expression of SOX4 in PGC was significantly correlated with favorable clinicopathologic features and was an independent prognostic factor for better overall and disease-free survival in patients. Therefore, SOX4 might be an auxiliary parameter for predicting malignant behavior for PGC. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1534825818694957.
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