ArticleScience signaling2012
Quantifying crosstalk among interferon-γ, interleukin-12, and tumor necrosis factor signaling pathways within a TH1 cell model.
Article in Science signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Advancements in research on the role of the key glycolytic enzyme hexokinase 2 in the regulation of tumor immune evasion (Review).Oncology letters · 2025Review
- Article
- Effect of nonsteroidal anti-inflammatory drugs on pelvic floor muscle regeneration in a preclinical birth injury rat model.American journal of obstetrics and gynecology · 2024Article
- IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting.Nature reviews. Gastroenterology & hepatology · 2019Review
- Melanoma exosomes deliver a complex biological payload that upregulates PTPN11 to suppress T lymphocyte function.Pigment cell & melanoma research · 2017Article
- Synergistic Communication between CD4+ T Cells and Monocytes Impacts the Cytokine Environment.Scientific reports · 2016Article
- Inferring the Impact of Regulatory Mechanisms that Underpin CD8+ T Cell Control of B16 Tumor GrowthFrontiers in pharmacology · 2016Article
- Interlocked positive and negative feedback network motifs regulate β-catenin activity in the adherens junction pathway.Molecular biology of the cell · 2015Article
- In silico model-based inference: an emerging approach for inverse problems in engineering better medicines.Current opinion in chemical engineering · 2015Article
- Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study.Journal for immunotherapy of cancer · 2015Review
- Downregulation of Runx3 is closely related to the decreased Th1-associated factors in patients with gastric carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Negative interactions and feedback regulations are required for transient cellular response.Scientific reports · 2014Article
- Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study.PLoS computational biology · 2014Article
- Exploring higher-order EGFR oligomerisation and phosphorylation--a combined experimental and theoretical approach.Molecular bioSystems · 2013Article
- Collapse of the tumor stroma is triggered by IL-12 induction of Fas.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.PLoS computational biology · 2013Article
- A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model.Integrative biology : quantitative biosciences from nano to macro · 2012Article
- An evolutionary perspective on anti-tumor immunity.Frontiers in oncology · 2012Article
- Downregulation of Hlx closely related to the decreased expressions of T-bet and Runx3 in patients with gastric cancer may be associated with a pathological event leading to the imbalance of Th1/Th2.Clinical & developmental immunology · 2012Article
- Understanding immunology via engineering design: the role of mathematical prototyping.Computational and mathematical methods in medicine · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
T helper (T(H)) cells integrate biochemical cues present in the tissue microenvironment and produce cytokines that orchestrate immune responses. Previous discoveries have revealed a qualitative understanding of how T(H) cells process this biochemical information; however, the lack of methods to quantify how well these depictions apply to a particular cell type limits our ability to translate our knowledge of the immune response from one biological system to another. We used model-based inference methods and quantitative flow cytometric analysis in mouse T(H)1 cells to determine the relative contributions of different putative branches in the signaling network that responds to the cytokine interleukin-12 (IL-12), which links innate and adaptive immunity. The response of T(H)1 cells to IL-12 exhibited hysteresis because it depended on both current and past exposure and engaged a positive feedback mechanism through the direct activation of signal transducer and activator of transcription 1. The hysteresis in the dose-response curve to IL-12 created a transient "memory" by sustaining cytokine secretion after the withdrawal of the stimulus. In summary, this combined experimental and computational approach illustrates how model-based inference can be used to better understand how cells process and act upon biochemical cues present in the tissue microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.