Evidence map›Paper›PMID 22510459›Full record

ReviewCold Spring Harbor perspectives in biology2012

Wnt signaling in neuromuscular junction development.

Kate Koles, Vivian Budnik

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 105 citations in OpenAlex.

  1. Regulation of motor neuron differentiation in thebioRxiv : the preprint server for biology · 2025
    Article
  2. Article
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  5. Article
  6. Article
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  8. TheFrontiers in synaptic neuroscience · 2024
    Article
  9. REEP1 Preserves Motor Function in SOD1Neuroscience bulletin · 2023
    Article
  10. Article
  11. Review
  12. PSINDB: the postsynaptic protein-protein interaction database.Database : the journal of biological databases and curation · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kate KolesDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, 01605, USA.
Vivian Budnik
University of Massachusetts Chan Medical School · US

Funding

The Wingless Transduction Pathway in Synapse DevelopmentR01MH070000 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BUDNIK, VIVIAN G. · 2004 to 2013
$3.6M
The Frizzled Nuclear Import Pathway in Synapse DevelopmentR01NS063228 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BUDNIK, VIVIAN G. · 2010 to 2017
$2.4M
NIMH NIH HHS R01 MH070000NINDS NIH HHS R01 NS063228
6 · The paper itself

Abstract

Wnt proteins are best known for their profound roles in cell patterning, because they are required for the embryonic development of all animal species studied to date. Besides regulating cell fate, Wnt proteins are gaining increasing recognition for their roles in nervous system development and function. New studies indicate that multiple positive and negative Wnt signaling pathways take place simultaneously during the formation of vertebrate and invertebrate neuromuscular junctions. Although some Wnts are essential for the formation of NMJs, others appear to play a more modulatory role as part of multiple signaling pathways. Here we review the most recent findings regarding the function of Wnts at the NMJ from both vertebrate and invertebrate model systems.

Indexed as

Signal TransductionAnimalsCaenorhabditis elegansDrosophilaHumansLigandsNeuromuscular JunctionWnt ProteinsLigandsWnt Proteins

Identifiers

PMID22510459
PMCPMC3367558
OpenAlexW2103376306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.