ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2012
Expansion of polyreactive B cells cross-reactive to HLA and self in the blood of a patient with kidney graft rejection.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Antibody Polyreactivity: A Challenger of Immune Paradigms.Immunology · 2025Review
- Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice.eLife · 2025Article
- Clones reactive to apoptotic cells and specific chemical adducts are prevalent among human thymic B cells.Frontiers in immunology · 2024Article
- Broad responses to chemical adducts shape the natural antibody repertoire in early infancy.Science advances · 2023Article
- Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection.Nature communications · 2021Article
- Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Review
- Is There a Role for Natural Antibodies in Rejection Following Transplantation?Transplantation · 2019Review
- New insights into immune mechanisms of antiperlecan/LG3 antibody production: Importance of T cells and innate B1 cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Heterogeneity of memory B cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Review
- Prevalence of polyreactive innate clones among graft--infiltrating B cells in human cardiac allograft vasculopathy.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
- New Answers to Old Conundrums: What Antibodies, Exosomes and Inflammasomes Bring to the Conversation. Canadian National Transplant Research Program International Summit Report.Transplantation · 2018Review
- Article
- Dynamics of B Cell Recovery In Kidney/Bone Marrow Transplant Recipients.Transplantation · 2017Article
- Th17 Responses to Collagen Type V, kα1-Tubulin, and Vimentin Are Present Early in Human Development and Persist Throughout Life.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017Article
- Polyreactive natural antibodies in transplantation.Current opinion in organ transplantation · 2017Review
- Complement in Kidney Transplantation.Frontiers in medicine · 2017Review
- Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood.Pediatric nephrology (Berlin, Germany) · 2016Article
- Evidence to Support a Contribution of Polyreactive Antibodies to HLA Serum Reactivity.Transplantation · 2016Article
- Expansion and somatic hypermutation of B-cell clones in rejected human kidney grafts.Transplantation · 2014Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
Antibody rejection is often accompanied by nondonor HLA specific antibodies (NDSA) and self-reactive antibodies that develop alongside donor-specific antibodies (DSA). To determine the source of these antibodies, we immortalized 107 B-cell clones from a kidney transplant recipient with humoral rejection. Two of these clones reacted to HLA class I or MICA. Both clones were also reactive to self-antigens and a lysate of a kidney cell line, hence revealing a pattern of polyreactivity. Monoclonality was verified by the identification of a single rearranged immunoglobulin heavy chain variable region (VH) sequence for each clone. By tracking their unique CDR3 sequence, we found that one such polyreactive clone was highly expanded in the patient blood, representing ~0.2% of circulating B cells. The VH sequence of this clone showed evidence of somatic mutations that were consistent with its memory phenotype and its expansion. Lastly, the reactivity of the expanded polyreactive B-cell clone was found in the patient serum at time of rejection. In conclusion, we provide here proof of principle at the clonal level that human antibodies can cross-react to HLA and self. Our findings strongly suggest that polyreactive antibodies contribute to DSA, NDSA as well as autoantibodies, in transplant recipients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.