ArticleMedical gas research2012
Are volatile anesthetics neuroprotective or neurotoxic?
Article in Medical gas research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- The Effect of General Anesthesia vs. Regional Anesthesia on Postoperative Delirium-A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Relationship between Surgery under General Anesthesia and the Development of Dementia: A Systematic Review and Meta-Analysis.BioMed research international · 2020Pooled it
- Sedation as an Immunomodulator of Inflammatory Responses in the Lung-Brain Axis of ARDS.International journal of molecular sciences · 2026Review
- Surgery May Be a Major Contributor for Postoperative Delirium in Patients With Elective Thoracic Aortic Aneurysm Procedures.CNS neuroscience & therapeutics · 2025Observational
- The impact of maternal anti-inflammatory drugs on surgical anesthesia-induced neuroinflammation and cognitive impairment in offspring mice.Frontiers in cellular neuroscience · 2024Article
- Immunopharmacological considerations of general anaesthetics for surgical procedures in the times of COVID-19: Correspondence.Annals of medicine and surgery (2012) · 2023Article
- HSP90 inhibitor 17AAG attenuates sevoflurane-induced neurotoxicity in rats and human neuroglioma cells via induction of HSP70.Journal of translational medicine · 2020Article
- Review Cerebral Ischemic Tolerance and Preconditioning: Methods, Mechanisms, Clinical Applications, and Challenges.Frontiers in neurology · 2020Review
- Neuroprotection against stroke and encephalopathy after cardiac surgery.Interventional medicine & applied science · 2019Review
- Volatile anaesthetics and postoperative delirium in older surgical patients-A secondary analysis of prospective cohort studies.Acta anaesthesiologica Scandinavica · 2019Article
- Isoflurane Use in the Treatment of Super-Refractory Status Epilepticus is Associated with Hippocampal Changes on MRI.Neurocritical care · 2017Article
- Article
- Critical role of P2X7 receptors in the neuroinflammation and cognitive dysfunction after surgery.Brain, behavior, and immunity · 2017Article
- Cerebral Ischemic Preconditioning: the Road So Far….Molecular neurobiology · 2016Review
- [Special aspects of analgosedation in cardiogenic shock patients].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2016Review
- Duration-dependent regulation of autophagy by isoflurane exposure in aged rats.Neuroscience bulletin · 2015Article
- Neonatal exposure to sevoflurane may not cause learning and memory deficits and behavioral abnormality in the childhood of Cynomolgus monkeys.Scientific reports · 2015Article
- The choice of general anesthetics may not affect neuroinflammation and impairment of learning and memory after surgery in elderly rats.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Article
- miRNA expression profile and involvement of Let-7d-APP in aged rats with isoflurane-induced learning and memory impairment.PloS one · 2015Article
- Prostate cancer cell malignancy via modulation of HIF-1α pathway with isoflurane and propofol alone and in combination.British journal of cancer · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Volatile anesthetics are one class of the most commonly used drugs. However, the mechanisms for these drugs to induce anesthesia are not fully understood and have been under intensive investigation. Two other effects of these anesthetics on the central nervous system, volatile anesthetics-induced neuroprotection and neurotoxicity, currently are hot research fields. Although data from animal studies for these two effects are extensive and convincing, clinical data for volatile anesthetics-induced neuroprotection are relatively weak. There is essentially lack of evidence to suggest volatile anesthetics-induced neurotoxicity in humans. In this regard, the contribution of general anesthesia/anesthetics to postoperative cognitive decline, a clinical entity whose existence has been supported by substantial evidence, also has not been established. This paper will be focused on reviewing the evidence, especially the clinical evidence, for volatile anesthetics-induced neuroprotection and neurotoxicity. Efforts will be devoted to facilitating the understanding of the two seemingly contradictory effects of these important drugs on the brain.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.